公开(公告)号：US20210214775A1

公开(公告)日：2021-07-15

申请号：US17252982

申请日：2019-06-28

Applicant: OSAKA UNIVERSITY ,  OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Kohji NISHIDA ,  Noriyasu HASHIDA ,  Tetsuya IIDA ,  Shota NAKAMURA ,  Daisuke MOTOOKA ,  Kazunobu ASAO ,  Satoru ANDO

IPC: C12Q1/689 ,  C12Q1/06

Abstract: It aims to construct a technology in which the onset or progression of an aging state or a specific disease can be evaluated in an objective and highly reproducible manner, and in particular, to provide a method of detecting conjunctival diseases such as conjunctival MALT lymphoma, and to provide an aging biomarker that serves as an indicator of the aging state.
A method of detecting a conjunctival disease using an ocular surface tissue, the method comprising a step of comparing a microbial community structure of a microbiota included in an ocular surface tissue specimen sampled from a healthy person, with a microbial community structure of a microbiota included in an ocular surface tissue specimen sampled from a subject to detect an ocular surface tissue specimen which is sampled from the subject evaluated as having the conjunctival disease based on a change in the microbial community structure between the healthy person and the subject, and an aging biomarker for detecting an aging state, the aging biomarker comprising a bacterial species which belongs to at least one family selected from Corynebacteriaceae family and Propionibacteriales family in an ocular surface tissue.

公开(公告)号：US20190284246A1

公开(公告)日：2019-09-19

申请号：US16097219

申请日：2017-04-25

Applicant: OSAKA UNIVERSITY ,  BIKENBIOMICS CO., LTD

Inventor： Shota NAKAMURA ,  Kazuki KAWAHARA ,  Hiroya OKI ,  Takuya YOSHIDA ,  Tadayasu OHKUBO ,  Yuji KOBAYASHI ,  Takahiro MARUNO ,  Daisuke MOTOOKA ,  Shigeaki MATSUDA ,  Toshio KODAMA ,  Tetsuya IIDA ,  Yasumitsu TSUJINO ,  Shunsuke FUKAKUSA

IPC: C07K14/245

Abstract: A peptide capable of preventing pathogenic bacteria from colonizing in digestive organs comprises a first domain having an amino acid sequence capable of binding to a minor pilin of IVb fimbriae, and a second domain having an amino acid sequence capable of multimerization, the second domain connect to the first domain via a linker sequence.