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公开(公告)号：US20230139808A1
公开(公告)日：2023-05-04
申请号：US18148672
申请日：2022-12-30
发明人： Takashi NAKAGAWA , Makoto SAKAMOTO , Kazuya YAMAGUCHI , Yuki TERAUCHI , Masamichi SHIRAKURA , Yasuo HARADA , Yutaka KOJIMA , Takumi SUMIDA
IPC分类号： C07D213/75 , C07D213/76
摘要： The present invention provides a novel compound having an excellent antitumor effect stability and metabolic stability. The compound of the present invention is represented by the following general formula (1) wherein R1 represents a halogen atom, an aryl group, an aryloxy group or a lower alkyl group optionally substituted with one or more halogen atoms; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; and; m represents an integer of 1 to 3; provided that when m represents 2 or 3, R1s are the same or different.
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公开(公告)号：US11630071B2
公开(公告)日：2023-04-18
申请号：US16645619
申请日：2018-06-22
发明人： Tetsuya Noda , Masanao Majima , Yuuya Shouji
IPC分类号： G01N21/94 , G01N21/552 , G01N21/64 , G01N21/958
摘要： An analysis method for detecting an amount of a substance by irradiating an analysis chip containing the substance and detecting a quantity of light output from the analysis chip. The analysis method including irradiating an incident surface of the analysis chip and another surface adjacent to the incident surface with detection light while changing a relative position of the detection light with respect to the analysis chip, detecting reflected light from the incident surface of the analysis chip, and acquiring information on a position of the analysis chip from a relationship between a quantity of the reflected light detected and the relative position. The analysis method determines if the analysis chip is abnormal when a quantity of target reflected light is equal to or lower than a predetermined light quantity.
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公开(公告)号：US20230089147A1
公开(公告)日：2023-03-23
申请号：US17904536
申请日：2021-02-24
发明人： Aram Oganesian , Nipun Davar , Jim Hwaicher Kou
IPC分类号： A61K31/706 , A61K9/20 , A61K9/00 , A61K9/48 , A61K31/7016 , A61K31/20 , A61K31/717
摘要： Embodiments of the present invention provide solid oral dosage forms that upon daily administration to a subject provide plasma levels of decitabine with a 5-day AUC for decitabine that is equivalent to the 5-day AUC for a daily IV dose of decitabine of 20 mg/m2 administered as a one hour (1 h) infusion. Also provided according to embodiments of the present invention are solid oral dosage forms wherein upon daily administration to a subject provides a pharmacodynamic effect that is equivalent to the pharmacodynamic effect for a daily intravenous dose of decitabine of 20 mg/m2 administered as a one hour (1 h) infusion. Also provided are methods of treatment using a solid oral dosage form according to an embodiment of the invention.
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公开(公告)号：US20230076111A1
公开(公告)日：2023-03-09
申请号：US17986855
申请日：2022-11-14
发明人： Jeremy FRANK , Nikhil PARGAONKAR , Raymond SCHMIDT , Robert AZEVEDO , Kurt SCHEINPFLUG , Nikolaus LEIST , Chris DONG , Hiren PATEL , Peter BJELETICH , Robert DUCK
摘要： Various methods and apparatuses are presented for an ingestible capsule that includes a digital, ingestible sensor component—or ingestible sensor—embedded into the capsule. The ingestible sensor component may be configured to activate upon coming into contact with conductive fluid, such as a body's stomach fluid. Once activated, the ingestible sensor component may be configured to perform various tasks, such as transmitting one or more signals and obtaining biometric data about the body that ingested the capsule.
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公开(公告)号：US11565450B2
公开(公告)日：2023-01-31
申请号：US16765316
申请日：2018-09-28
发明人： Takehiko Goshima , Yoshifumi Imazu , Kenta Fuji
摘要： An injection molded article is obtained by injection molding a molten resin into a mold. The injection molded article includes: a base as a thin plate-shaped member that is connected to a gate of the mold; and a plurality of protrusions each integrally molded on the base and having a thickness greater than a plate thickness of the base. The plurality of protrusions have holes each extending through the base, and the holes in the respective protrusions are connected through another component to form a flow channel. A processed region processed to have a surface roughness greater than a surface roughness of a mirror surface region including a region between the holes on the base is formed in a projected region where a region having a predetermined thickness value is projected on the base.
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公开(公告)号：US20230027710A1
公开(公告)日：2023-01-26
申请号：US17827253
申请日：2022-05-27
发明人： Yasushi NAKAGAWA , Naoyuki DEGUCHI , Keisuke HAMAMOTO , Masamichi TOBA , Soh IWASHITA , Mina TSUBOUCHI , Kyungtak KWAK , Miho YOSHIE
摘要： In an information providing method, purchase data indicating a purchase history of a control customer is acquired, and a merchandise category to which at least one merchandise belongs is determined from the purchase data. In this method, an extent of a potential health symptom of a target customer is further predicted using a health predictive model having the merchandise category to which at least one merchandise included in the purchase history belongs and an extent of the health symptom correlated therein, and the merchandise category. In the method, health information indicating the extent of the predicted health symptom is provided to the target customer.
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公开(公告)号：US20230017155A1
公开(公告)日：2023-01-19
申请号：US17941627
申请日：2022-09-09
发明人： Kazunori GOTO , Jun NAKAHIGASHI , Atsuya SATO , Yosuke HIRAYAMA , Moeri HORIKOSHI , Noriyuki KOUDA , Syoichiro INOUE , Ikutaro SATO , Manami KATO
IPC分类号： A61K31/4985 , A61P25/20 , A61P25/22
摘要： Provided is a heat shock protein expression-inducing agent, more specifically, a heat shock protein expression-inducing agent comprising a compound represented by formula (I): wherein R is a lower alkyl, phenyl, or hydroxyphenyl, or a salt thereof.
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公开(公告)号：US11551790B2
公开(公告)日：2023-01-10
申请号：US15673870
申请日：2017-08-10
发明人： John P. Docherty , Ainslie Hatch , Ruth Ross , Dawn I. Velligan , Peter Weiden
摘要： In some embodiments, a system includes an ingestible signal generator coupled to a medication and configured to generate a body-transmissible signal upon ingestion by a user. The system also includes a receiver, the receiver including a sensor configured to detect the body-transmissible signal, the receiver configured to generate and wirelessly transmit a sensor signal based on the body-transmissible signal. The system also includes a user device. A processor of the user device is configured to wirelessly monitor the sensor for the sensor signal and, in response to not receiving the sensor signal within a predetermined time period, generate a notification. The processor is further configured to send a signal to present the notification and receive a response to the notification from the user. The processor is also configured to identify at least one trend associated with the sensor signal and the medication, and perform an action based thereon.
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公开(公告)号：US20220411386A1
公开(公告)日：2022-12-29
申请号：US17859675
申请日：2022-07-07
发明人： Naohiko Kanai , Takayuki Yasutomi , Ryosuke Hirota
IPC分类号： C07D263/32
摘要： Provided is a crystal of a specific oxazole compound that has specific inhibitory activity against PDE4, and that shows excellent stability. Specifically, provided is a crystal of an oxazole compound represented by formula (5) wherein the crystal has peaks at diffraction angles 2θ(°) of 9.6±0.2, 19.1±0.2, and 21.2±0.2 in an X-ray powder diffraction pattern measured using CuKα characteristic X-rays.
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公开(公告)号：US20220387423A1
公开(公告)日：2022-12-08
申请号：US17755832
申请日：2020-11-11
发明人： Taku KEMMOCHI , Hiroyuki YAMAZAKI , Yoshikazu OKA , Mika KOSEKI
IPC分类号： A61K31/496 , A61K9/20 , A61K9/00
摘要： Provided is an orally disintegrating tablet comprising brexpiprazole or a salt thereof that rapidly disintegrates in the oral cavity while having hardness suitable for practical use.
More specifically, provided is an orally disintegrating tablet comprising (A) brexpiprazole or a salt thereof, (B) D-mannitol, (C) partially pregelatinized starch, and (D) a lubricant.
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