公开(公告)号：US20250042982A1

公开(公告)日：2025-02-06

申请号：US18717136

申请日：2022-12-06

Applicant: OSAKA UNIVERSITY ,  PERIOTHERAPIA CO., LTD.

Inventor： Yoshiaki TANIYAMA ,  Fumihiro SANADA ,  Ryuichi MORISHITA

IPC: C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An object is to provide a novel antibody or antigen-binding fragment thereof against exon 21 of human periostin. The object is achieved by an antibody or antigen-binding fragment thereof bindable to a conformational epitope on human periostin, wherein the epitope contains the amino acid sequence A represented by SEQ ID NO: 61 and the amino acid sequence B represented by any one of SEQ ID NOs: 62 to 64.

公开(公告)号：US20190106484A1

公开(公告)日：2019-04-11

申请号：US16168275

申请日：2018-10-23

Applicant: OSAKA UNIVERSITY

Inventor： Yoshiaki TANIYAMA ,  Ryuichi MORISHITA ,  Junya AZUMA ,  Fumihiro SANADA ,  Naruto KATSURAGI

IPC: C07K16/18 ,  C07K14/47 ,  C12N5/12 ,  G01N33/68

Abstract: The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is involved, and also provides an inhibitor of a periostin isoform having cell adhesion activity.

公开(公告)号：US20160108109A1

公开(公告)日：2016-04-21

申请号：US14772122

申请日：2014-03-06

Applicant: OSAKA UNIVERSITY

Inventor： Yoshiaki TANIYAMA ,  Ryuichi MORISHITA ,  Junya AZUMA ,  Fumihiro SANADA ,  Naruto KATSURAGI

IPC: C07K16/18 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C12N5/12 ,  G01N33/68 ,  G01N2333/47

Abstract: The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is involved, and also provides an inhibitor of a periostin isoform having cell adhesion activity.

Abstract translation: 本发明提供了用于预防或治疗涉及具有细胞粘附活性的骨膜素异构体的炎症相关疾病的药物，并且还提供了具有细胞粘附活性的骨膜素同种型的抑制剂。