公开(公告)号：US20210046190A1

公开(公告)日：2021-02-18

申请号：US16965807

申请日：2019-01-30

Applicant: OSAKA UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Masaki MORI ,  Hideshi ISHII ,  Masamitsu KONNO ,  Hidetoshi EGUCHI ,  Naotsugu HARAGUCHI ,  Reishi TOSHIYAMA ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO

IPC: A61K47/64 ,  A61P35/00 ,  A61K31/513 ,  A61K31/704 ,  A61K33/243

Abstract: An object to be achieved by the present invention is to provide a technique for enhancing the anticancer effect of ubenimex; in particular, enhancing its anticancer effect on solid cancer. This object can be achieved by a compound containing a chain structure in which a plurality of ubenimex molecules is linked to a chain polymer.

公开(公告)号：US20220101147A1

公开(公告)日：2022-03-31

申请号：US17418168

申请日：2019-12-27

Applicant: OSAKA UNIVERSITY

Inventor： Masamitsu KONNO ,  Hideshi ISHII ,  Masaki MORI ,  Ayumu ASAI ,  Jun KOSEKI

IPC: G06N3/12 ,  G06N20/00

Abstract: The present disclosure relates to predicting trait information from the genetic information of individuals, and generating a model therefor. Learning is performed using a plurality of types of genetic information from a plurality of individuals, and a model for predicting trait information is generated. For said learning, it is possible to create images of the genetic information, and provide the same to said learning. The images in the present disclosure can store both sequence information and expression information. Moreover, the layout of genetic factors in the images can be optimized. Said learning can be performed as split learning, and the data after said split learning can be consolidated.

公开(公告)号：US20190250149A1

公开(公告)日：2019-08-15

申请号：US16249444

申请日：2019-01-16

Applicant: SUMITOMO RUBBER INDUSTRIES, LTD. ,  YAMAGATA UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Yasuhisa MINAGAWA ,  Masaru TANAKA ,  Takashi HOSHIBA ,  Haruka EMURA ,  Masaki MORI ,  Hirofumi YAMAMOTO ,  Naotsugu HARAGUCHI

IPC: G01N33/50 ,  B01D21/26

CPC classification number: G01N33/5091 ,  B01D21/262 ,  G01N33/543 ,  G01N33/574

Abstract: The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: centrifuging sampled blood or biological fluid at a centrifugal force of 1000 to 3000 G; and capturing specific cells therefrom onto a hydrophilic polymer layer.

公开(公告)号：US20170128487A1

公开(公告)日：2017-05-11

申请号：US15119862

申请日：2015-02-20

Applicant: HIROFUMI YAMAMOTO ,  MASAKI MORI ,  OSAKA UNIVERSITY

Inventor： Hirofumi YAMAMOTO ,  Masaki MORI ,  Yuichiro DOKI ,  Xin WU

IPC: A61K33/06 ,  A61K31/704 ,  A61K31/555 ,  A61K31/337 ,  A61K31/513 ,  A61K33/24

CPC classification number: A61K33/06 ,  A61K31/337 ,  A61K31/513 ,  A61K31/555 ,  A61K31/704 ,  A61K33/24 ,  A61K2300/00

Abstract: An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.

公开(公告)号：US20190250151A1

公开(公告)日：2019-08-15

申请号：US16249527

申请日：2019-01-16

Applicant: SUMITOMO RUBBER INDUSTRIES, LTD. ,  YAMAGATA UNIVERSITY ,  OSAKA UNIVERSITY

Inventor： Yasuhisa MINAGAWA ,  Masaru TANAKA ,  Takashi HOSHIBA ,  Haruka EMURA ,  Masaki MORI ,  Hirofumi YAMAMOTO ,  Naotsugu HARAGUCHI

IPC: G01N33/50 ,  B01D21/26

CPC classification number: G01N33/5091 ,  B01D21/262 ,  G01N33/543 ,  G01N33/574

Abstract: The present invention provides a method for capturing specific cells (e.g. many types of cancer cells, including cancer cells not expressing EpCAM) and a method for analysis of specific cells involving the method. Included is a method for capturing specific cells present in blood or biological fluid, the method including: subjecting sampled blood or biological fluid to enrichment; and capturing specific cells therefrom onto a hydrophilic polymer layer in a flow field.