公开(公告)号：US20210046190A1

公开(公告)日：2021-02-18

申请号：US16965807

申请日：2019-01-30

Applicant: OSAKA UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Masaki MORI ,  Hideshi ISHII ,  Masamitsu KONNO ,  Hidetoshi EGUCHI ,  Naotsugu HARAGUCHI ,  Reishi TOSHIYAMA ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO

IPC: A61K47/64 ,  A61P35/00 ,  A61K31/513 ,  A61K31/704 ,  A61K33/243

Abstract: An object to be achieved by the present invention is to provide a technique for enhancing the anticancer effect of ubenimex; in particular, enhancing its anticancer effect on solid cancer. This object can be achieved by a compound containing a chain structure in which a plurality of ubenimex molecules is linked to a chain polymer.

公开(公告)号：US20230078523A1

公开(公告)日：2023-03-16

申请号：US17801115

申请日：2021-01-21

Applicant: MENICON CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Koji UESUGI ,  Hidetoshi EGUCHI ,  Kunihito GOTOH

IPC: A61L24/10 ,  A61L24/00

Abstract: A material or method that can serve as an alternative to a related-art digestive fluid leak preventative material and method of preventing a leak of a digestive fluid, the digestive fluid leak preventative material includes a self-assembling peptide gel, has an adhesion persistence ratio with respect to a collagen sheet of at least 40%, and has a decomposition ratio of 35% or less in pancreatic juice treatment at 37° C. for 7 days.

公开(公告)号：US20250082690A1

公开(公告)日：2025-03-13

申请号：US18767567

申请日：2024-07-09

Applicant: TERUMO KABUSHIKI KAISHA ,  OSAKA UNIVERSITY

Inventor： Hidetoshi EGUCHI ,  Yoshito TOMIMARU ,  Shigeru MIYAGAWA ,  Keisuke TOYA ,  Fumiya OHASHI

IPC: A61K35/34 ,  A61P1/16 ,  C12N5/077

Abstract: A sheet-shaped cell culture comprising skeletal myoblasts for treating liver dysfunction or improving liver function. A method for producing the sheet-shaped cell culture, including a step of seeding a cell population comprising skeletal myoblasts on a culture substrate, a step of forming a sheet of the cell population into a sheet to form a sheet-shaped cell culture, and a step of detaching the formed sheet-shaped cell culture from the culture substrate. A method for treating liver dysfunction, including a step of applying the sheet-shaped cell culture to a site exhibiting the liver dysfunction.

公开(公告)号：US20240358765A1

公开(公告)日：2024-10-31

申请号：US18767576

申请日：2024-07-09

Applicant: Terumo Kabushiki Kaisha ,  Osaka University

Inventor： Hidetoshi EGUCHI ,  Yoshito TOMIMARU ,  Shigeru MIYAGAWA ,  Keisuke TOYA ,  Fumiya OHASHI

IPC: A61K35/34 ,  A61P1/16 ,  C12N5/077

CPC classification number: A61K35/34 ,  A61P1/16 ,  C12N5/0658 ,  C12N2502/28

Abstract: A composition comprising skeletal myoblasts for treating liver dysfunction or improving liver function, in which the liver dysfunction can be hepatitis, liver fibrosis, liver cirrhosis, liver cancer, or liver failure. The composition can be used for promoting the proliferation of liver cells, regeneration of the liver tissue and/or angiogenesis, and providing a method for treating liver dysfunction, including a step of treating applying the composition to a site exhibiting liver dysfunction.