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公开(公告)号：US20210388072A1
公开(公告)日：2021-12-16
申请号：US17281874
申请日：2019-10-02
Applicant: OSPEDALE SAN RAFFAELE S.R.L. , ENTHERA S.R.L.
Inventor： Paolo FIORINA , Francesca D'ADDIO , Francesca ZAGARI
IPC: C07K16/22
Abstract: The present invention relates to an antibody or antigen binding fragment thereof that binds specifically to IGFBP3 and does not displace the binding of IGF-I to IGFBP3. The antibody inhibits or reduces the binding of IGFBP3 to the TMEM219 receptor. The invention also relates to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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