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公开(公告)号：US20230242649A1
公开(公告)日：2023-08-03
申请号：US17777021
申请日：2020-11-16
Applicant: ENTHERA S.R.L.
Inventor： Paolo FIORINA , Giovanni AMABILE , Francesca D'ADDIO
CPC classification number: C07K16/2863 , A61P3/10 , C12N15/63 , C07K2317/565 , C07K2317/92 , C07K2317/24
Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind specifically to the IGFBP3 receptor, namely TMEM219, to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20240368290A1
公开(公告)日：2024-11-07
申请号：US18772062
申请日：2024-07-12
Applicant: ENTHERA S.R.L.
Inventor： Paolo FIORINA , Giovanni AMABILE , Francesca D'ADDIO
Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind specifically to the IGFBP3 receptor, namely TMEM219, to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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Patent Agency Ranking
公开(公告)号：US20230039165A1
公开(公告)日：2023-02-09
申请号：US17778814
申请日：2020-11-20
Applicant: ENTHERA S.R.L.
Inventor： Giovanni AMABILE , Paolo FIORINA , Francesca D'ADDIO
Abstract: The present invention relates to antibodies or antigen binding fragment thereof that binds specifically to IGFBP3. The antibody inhibits or reduces the binding of IGFBP3 to the TMEM219 receptor. The invention also relates to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US12221476B2
公开(公告)日：2025-02-11
申请号：US17281874
申请日：2019-10-02
Applicant: OSPEDALE SAN RAFFAELE S.R.L. , ENTHERA S.R.L.
Inventor： Paolo Fiorina , Francesca D'Addio , Francesca Zagari
Abstract: The present invention relates to an antibody or antigen binding fragment thereof that binds specifically to IGFBP3 and does not displace the binding of IGF-I to IGFBP3. The antibody inhibits or reduces the binding of IGFBP3 to the TMEM219 receptor. The invention also relates to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20230192827A1
公开(公告)日：2023-06-22
申请号：US17800407
申请日：2021-02-19
Applicant: ENTHERA S.R.L.
Inventor： Giovanni AMABILE
CPC classification number: C07K16/18 , A61P11/00 , A61P19/04 , C07K2317/21 , C07K2317/24
Abstract: The present invention relates to inhibitors of IGFBP5 and/or of at least one of its receptors, wherein said inhibitor has anti-fibrotic effect, methods for their production, pharmaceutical compositions containing said inhibitors, and uses thereof. In particular, the invention relates to antibodies or antigen binding fragments thereof that bind specifically to human IGFBP5 and/or to at least one of its receptors.
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公开(公告)号：US12221485B2
公开(公告)日：2025-02-11
申请号：US18772062
申请日：2024-07-12
Applicant: ENTHERA S.R.L.
Inventor： Paolo Fiorina , Giovanni Amabile , Francesca D'Addio
Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind specifically to the IGFBP3 receptor, namely TMEM219, to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20210388072A1
公开(公告)日：2021-12-16
申请号：US17281874
申请日：2019-10-02
Applicant: OSPEDALE SAN RAFFAELE S.R.L. , ENTHERA S.R.L.
Inventor： Paolo FIORINA , Francesca D'ADDIO , Francesca ZAGARI
IPC: C07K16/22
Abstract: The present invention relates to an antibody or antigen binding fragment thereof that binds specifically to IGFBP3 and does not displace the binding of IGF-I to IGFBP3. The antibody inhibits or reduces the binding of IGFBP3 to the TMEM219 receptor. The invention also relates to methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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