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![PYRAZOLO[3,4-B]PYRAZINE SHP2 PHOSPHATASE INHIBITORS](/abs-image/US/2023/02/16/US20230049719A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230049719A1
公开(公告)日：2023-02-16
申请号：US17753048
申请日：2020-08-20
IPC分类号： A61K31/4985 , A61K45/06 , A61P35/00 , A61K9/20 , A61K9/48 , A61K9/00 , A61K47/10 , A61K47/26 , A61K9/19 , C07D519/00 , C07D487/04
摘要： The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：US20220363693A1
公开(公告)日：2022-11-17
申请号：US17262341
申请日：2019-07-23
发明人： Tadashi SHIMAMURA , Ryo KATO , Risako MIURA , Takashi MITA , Takahiro OGAWA , Yufu SAGARA , Christopher Norbert JOHNSON , Steven HOWARD , James Edward Harvey DAY , Jeffrey David ST. DENIS , John Walter LIEBESCHUETZ
IPC分类号： C07D519/00 , C07D487/04 , C07F7/08
摘要： A compound of formula (I): wherein Ring A, Q, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, X, a, b, c and d are as defined in the specification.
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公开(公告)号：US20210107908A1
公开(公告)日：2021-04-15
申请号：US16976631
申请日：2019-03-01
发明人： Christopher Norbert JOHNSON , Ildiko Maria BUCK , Gianni CHESSARI , James Edward Harvey DAY , Hideto FUJIWARA , Christopher Charles Frederick HAMLETT , Steven Douglas HISCOCK , Rhian Sara HOLVEY , Steven HOWARD , John Walter LIEBESCHUETZ , Nicholas John PALMER , Jeffrey David ST DENIS , David Geoffrey TWIGG , Andrew James WOODHEAD
IPC分类号： C07D487/04 , C07D519/00 , A61K31/4985 , A61K45/06 , A61K31/517 , A61K31/5377
摘要： The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
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