公开(公告)号：US20160095962A1

公开(公告)日：2016-04-07

申请号：US14888973

申请日：2014-05-28

申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.

发明人： Tatsuru FUKUDA ,  Hirofumi TAMURA

IPC分类号： A61L31/04 ,  A61L31/14

CPC分类号： A61L31/041 ,  A61L31/042 ,  A61L31/145 ,  A61L2400/06 ,  C08L5/04

摘要： An object of the present invention to provide an antiadhesive material designed to have time-varying fluidity as it exhibits a gel form of high fluidity at the time of administration, and exhibits a gel form of low fluidity after it is administered to an incised and sutured site. A powdery antiadhesive material to be mixed with an aqueous solvent upon use containing alginic acid and/or a salt thereof, that is configured to be mixed with the aqueous solvent upon use so that the viscosity at 37° C. is less than or equal to 70 mPas·s at the time of 5 minutes after mixing with the aqueous solvent, and the viscosity at 37° C. is more than or equal to 120 mPas·s at the time of 60 minutes after mixing, will have high fluidity at the time of administration when it is mixed with an aqueous solvent upon use in a clinical scene, and have low fluidity after it is administered to an incised and sutured site, and thus is capable of satisfying both the excellent operability and the antiadhesive effect.

摘要翻译： 本发明的目的是提供一种抗粘剂材料，其设计成具有随时间变化的流动性，因为其在施用时具有高流动性的凝胶形式，并且在施用于切割和缝合后呈现出低流动性的凝胶形式 现场。 在使用时与含水溶剂混合的粉状防粘剂，含有藻酸和/或其盐，其被配置为在使用时与水性溶剂混合，使得在37℃下的粘度小于或等于 在与水性溶剂混合后5分钟时70mPas·s，混合后60分钟时，37℃下的粘度大于或等于120mPas·s，在流动性 在临床现场使用时与水性溶剂混合时的给药时间，并且在向切割缝合部位施用后具有低流动性，因此能够同时满足优异的操作性和抗粘连性。

公开(公告)号：US20200282005A1

公开(公告)日：2020-09-10

申请号：US16756499

申请日：2018-10-19

申请人： OTSUKA PHARMACEUTICAL FACTORY, INC.

发明人： Namiki FUJII ,  Yuichiro YOSHIOKA ,  Tatsuru FUKUDA

IPC分类号： A61K38/06 ,  A61K38/04 ,  A61K38/17 ,  A61K38/10 ,  A61K9/06 ,  A61P41/00

摘要： The purpose of the present invention is to provide an adhesion prevention material capable of exhibiting excellent adhesion preventive effect. This adhesion prevention material concurrently uses: (A) a peptide (A-1) having an amino acid sequence-(X-Pro-Y)n-[wherein X represents an arbitrary defined amino acid, Pro represents proline, Y represents hydroxyproline or proline, and n is an integer between 1 and 10] and/or a peptide (A-2) having an amino acid sequence-(Pro-Y)m-[wherein Pro represents proline, Y represents hydroxyproline or proline, and m is an integer between 1-10]; and (B) a gelatin gel. This adhesion prevention material exhibits a dramatically enhanced adhesion preventive effect as compared with the case where the abovementioned components are used individually, and in particular, has a markedly superior effect against adhesion of tendons.