公开(公告)号：US12090162B2

公开(公告)日：2024-09-17

申请号：US18384000

申请日：2023-10-26

申请人： Oculis Operations Sarl

发明人： Thorsteinn Loftsson ,  Zoltán Fulop

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/40 ,  A61P27/02 ,  A61P29/00

CPC分类号： A61K31/573 ,  A61K9/0048 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K47/40 ,  A61P27/02 ,  A61P29/00

摘要： The present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a drug which is prone to oxidation, said method comprising the addition of an additive to prevent oxidation of the drug which is prone to oxidation. In particular, the present disclosure relates to a method for stabilizing the pH of an aqueous composition comprising a corticosteroid, said method comprising the addition of an additive to prevent oxidation of the corticosteroid. The present disclosure also relates to a composition comprising a corticosteroid and an additive to prevent oxidation of the corticosteroid.