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1.发明授权Water insoluble polymer: indigestible water-soluble polysaccharide film coatings for colon targeting 有权水不溶性聚合物：难消化的水溶性多糖薄膜包衣用于结肠靶向公开(公告)号：US09107819B2
公开(公告)日：2015-08-18
申请号：US13126236
申请日：2009-10-27
申请人： Olaf Haeusler , Daniel Wils , Juergen Siepmann , Youness Karrout
发明人： Olaf Haeusler , Daniel Wils , Juergen Siepmann , Youness Karrout
CPC分类号： A61K9/0053 , A61K9/2826 , A61K9/2846 , A61K47/36
摘要： A controlled release pharmaceutical dosage form for controlled release of an active ingredient, includes an active ingredient coated by a polymeric mixture of: at least a water insoluble polymer; and at least an indigestible water-soluble oligosaccharide. The use and method of making the same are also described.
摘要翻译： 用于控制释放活性成分的控制释放药物剂型包括通过至少一种水不溶性聚合物的聚合物混合物包被的活性成分; 和至少难消化的水溶性寡糖。 还描述了制造它们的用途和方法。
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2.发明申请公开(公告)号：US20110256230A1
公开(公告)日：2011-10-20
申请号：US13126236
申请日：2009-10-27
申请人： Olaf Haeusler , Daniel Wils , Juergen Siepmann , Youness Karrout
发明人： Olaf Haeusler , Daniel Wils , Juergen Siepmann , Youness Karrout
CPC分类号： A61K9/0053 , A61K9/2826 , A61K9/2846 , A61K47/36
摘要： A controlled release pharmaceutical dosage form for controlled release of an active ingredient, includes an active ingredient coated by a polymeric mixture of: at least a water insoluble polymer; and at least an indigestible water-soluble oligosaccharide. The use and method of making the same are also described.
摘要翻译： 用于控制释放活性成分的控制释放药物剂型包括通过至少一种水不溶性聚合物的聚合物混合物包被的活性成分; 和至少难消化的水溶性寡糖。 还描述了制造它们的用途和方法。
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3.发明申请公开(公告)号：US20110200680A1
公开(公告)日：2011-08-18
申请号：US13126212
申请日：2009-10-27
申请人： Olaf Haeusler , Daniel Wils , Juergen Siepmann , Youness Karrout
发明人： Olaf Haeusler , Daniel Wils , Juergen Siepmann , Youness Karrout
CPC分类号： A61K9/0053 , A61K9/2826 , A61K9/2846 , A61K47/36
摘要： A controlled release delivery dosage form for controlled release of an active ingredient, includes an active ingredient coated in a polymeric mixture of: at least a water insoluble polymer and a starch composition including at least one component selected from the group consisting of a starch having an amylose content of between 20 and 45%, a modified starch having an amylose content of between 50 and 80% and a legume starch. The present invention also relates to the use and method for making the same.
摘要翻译： 用于控制释放活性成分的控释递送剂型包括涂覆在聚合物混合物中的活性成分：至少水不溶性聚合物和淀粉组合物，所述淀粉组合物包含至少一种选自以下的组分：淀粉，其具有 直链淀粉含量为20至45％，直链淀粉含量为50至80％的改性淀粉和豆科植物淀粉。 本发明还涉及其制备方法和用途。
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公开(公告)号：US09358205B2
公开(公告)日：2016-06-07
申请号：US13880158
申请日：2011-10-28
CPC分类号： A61K9/0002 , A61K9/1652 , A61K9/205
摘要： A controlled-release oral pharmaceutical composition of at least an active agent, including: a) a lipophilic matrix consisting of lipophilic compounds and/or amphiphilic compounds; and b) an hydrophilic matrix, wherein the hydrophilic matrix includes at least an indigestible polysaccharide, the active ingredient being dispersed in the lipophilic and/or the hydrophilic matrix.The present invention also relates to a process for the preparation of such a pharmaceutical composition.
摘要翻译： 至少一种活性剂的控释药物组合物，包括：a）由亲脂性化合物和/或两亲性化合物组成的亲脂性基质; 和b）亲水基质，其中所述亲水基质包括至少不消化的多糖，所述活性成分分散在亲脂基和/或亲水基质中。 本发明还涉及制备这种药物组合物的方法。
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公开(公告)号：US20130202691A1
公开(公告)日：2013-08-08
申请号：US13880158
申请日：2011-10-28
IPC分类号： A61K9/00
CPC分类号： A61K9/0002 , A61K9/1652 , A61K9/205
摘要： A controlled-release oral pharmaceutical composition of at least an active agent, including: a) a lipophilic matrix consisting of lipophilic compounds and/or amphiphilic compounds; and b) an hydrophilic matrix, wherein the hydrophilic matrix includes at least an indigestible polysaccharide, the active ingredient being dispersed in the lipophilic and/or the hydrophilic matrix.The present invention also relates to a process for the preparation of such a pharmaceutical composition.
摘要翻译： 至少一种活性剂的控释药物组合物，包括：a）由亲脂性化合物和/或两亲性化合物组成的亲脂性基质; 和b）亲水基质，其中所述亲水基质包括至少不消化的多糖，所述活性成分分散在亲脂基和/或亲水基质中。 本发明还涉及制备这种药物组合物的方法。
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