公开(公告)号：US07341708B1

公开(公告)日：2008-03-11

申请号：US11613963

申请日：2006-12-20

申请人： Oleksandr Miroshnychenko ,  Xueju Xie ,  Jason Jiang-Chung Ko

发明人： Oleksandr Miroshnychenko ,  Xueju Xie ,  Jason Jiang-Chung Ko

IPC分类号： A61K51/00 ,  A61M36/14

CPC分类号： A61K31/28 ,  A23L33/175 ,  A61K31/195 ,  A61K31/295 ,  A61K31/30 ,  A61K31/315

摘要： A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a metal hydroxyl amino acetate. The second stage comprises contacting the metal hydroxyl amino acetate from the first stage, with at least one amino-containing compound provided in excess thereby producing a reaction solution containing an amino acid chelate reaction product comprising a metal ion bound to a plurality of amino acid ligands wherein the plurality of amino acid ligands is equal to the coordination number of the metal ion, and then separating the amino acid chelate from the reaction solution. The second stage may include a plurality of steps for sequentially reacting the reaction product with a plurality of amino-containing compounds. The amino acid chelates thus produced can be incorporated into compositions comprising beverages, foodstuffs, nutraceuticals and pharmaceutical adjuvants.

摘要翻译： 制备基本上纯的氨基酸螯合物的两阶段方法，其中第一步包括使金属氧化物或氢氧化物的金属离子与氨基酸接触，从而产生金属羟基氨基乙酸酯。 第二阶段包括使来自第一阶段的金属羟基氨基乙酸酯与至少一种过量提供的含氨基化合物接触，从而产生含有氨基酸螯合反应产物的反应溶液，所述氨基酸螯合反应产物包含与多个氨基酸配体结合的金属离子 其中多个氨基酸配体等于金属离子的配位数，然后将氨基酸螯合物与反应溶液分离。 第二阶段可以包括使反应产物与多种含氨基化合物顺序反应的多个步骤。 由此生产的氨基酸螯合物可以掺入包含饮料，食品，保健品和药物佐剂的组合物中。

公开(公告)号：US20080096804A1

公开(公告)日：2008-04-24

申请号：US11643846

申请日：2006-12-22

申请人： Oleksandr Miroshnychenko ,  Xueju Xle ,  Jason Ko

发明人： Oleksandr Miroshnychenko ,  Xueju Xle ,  Jason Ko

IPC分类号： A61K38/16 ,  A61K31/28 ,  A61K31/555

CPC分类号： A61K31/555 ,  A61K31/28

摘要： A two-stage method of preparing essentially pure amino acid chelates, wherein the first stage comprises contacting a metal ion from a metal oxide or hydroxide with an amino acid thereby producing a metal hydroxyl amino acetate. The second stage comprises contacting the metal hydroxyl amino acetate from the first stage, with at least one amino-containing compound provided in excess thereby producing a reaction solution containing an amino acid chelate reaction product comprising a metal ion bound to a plurality of amino acid ligands wherein the plurality of amino acid ligands is equal to the coordination number of the metal ion, and then separating the amino acid chelate from the reaction solution. The second stage may include a plurality of steps for sequentially reacting the reaction product with a plurality of amino-containing compounds. The amino acid chelates thus produced can be incorporated into compositions comprising beverages, foodstuffs, nutraceuticals and pharmaceutical adjuvants.

摘要翻译： 制备基本上纯的氨基酸螯合物的两阶段方法，其中第一步包括使金属氧化物或氢氧化物的金属离子与氨基酸接触，从而产生金属羟基氨基乙酸酯。 第二阶段包括使来自第一阶段的金属羟基氨基乙酸酯与至少一种过量提供的含氨基化合物接触，从而产生含有氨基酸螯合反应产物的反应溶液，所述氨基酸螯合反应产物包含与多个氨基酸配体结合的金属离子 其中多个氨基酸配体等于金属离子的配位数，然后将氨基酸螯合物与反应溶液分离。 第二阶段可以包括使反应产物与多个含氨基化合物顺序反应的多个步骤。 由此生产的氨基酸螯合物可以掺入包含饮料，食品，保健品和药物佐剂的组合物中。