公开(公告)号：US09359269B2

公开(公告)日：2016-06-07

申请号：US12092392

申请日：2006-09-15

申请人： Oliver Huttenloch ,  Patrick Deck ,  Holger Ganz ,  Michael Mauβ ,  Wolfgang Körnig ,  Michael Bock

发明人： Oliver Huttenloch ,  Patrick Deck ,  Holger Ganz ,  Michael Mauβ ,  Wolfgang Körnig ,  Michael Bock

IPC分类号： C07B63/00 ,  C07F9/22

CPC分类号： C07F9/224 ,  C07B63/00

摘要： A process for the removal of acids from reaction mixtures, comprising at least one product of value which is sparingly soluble in water, by at least one unpolar amine as an auxiliary base, which includes: a) reacting the auxiliary base with the acid with formation of a salt; b) reacting the salt formed in step a) with a further base which accepts the acid with liberation of the auxiliary base and combines with the acid to be accepted from the auxiliary base to form a salt which is very readily soluble in water; c) extraction of the mixture obtained in step b) with water or an aqueous medium, wherein the salt of the further base dissolves in the aqueous phase and the product of value, or the solution of the product of value, in a suitable solvent and the auxiliary base form at least one separate nonaqueous phase; and d) removal by distillation of at least part of any solvent present from the at least one nonaqueous phase obtained in step c), to form two nonmiscible liquid phases.

公开(公告)号：US20080287709A1

公开(公告)日：2008-11-20

申请号：US12092392

申请日：2006-09-15

申请人： Oliver Huttenloch ,  Patrick Deck ,  Holger Ganz ,  Michael Mauss ,  Wolfgang Kornig ,  Michael Bock

发明人： Oliver Huttenloch ,  Patrick Deck ,  Holger Ganz ,  Michael Mauss ,  Wolfgang Kornig ,  Michael Bock

IPC分类号： C07F9/22 ,  B01D1/00 ,  B01D11/04

CPC分类号： C07F9/224 ,  C07B63/00

摘要： A process for the removal of acids from reaction mixtures, comprising at least one product of value which is sparingly soluble in water, by at least one unpolar amine as an auxiliary base, which includes: a) reacting the auxiliary base with the acid with formation of a salt; b) reacting the salt formed in step a) with a further base which accepts the acid with liberation of the auxiliary base and combines with the acid to be accepted from the auxiliary base to form a salt which is very readily soluble in water; c) extraction of the mixture obtained in step b) with water or an aqueous medium, wherein the salt of the further base dissolves in the aqueous phase and the product of value, or the solution of the product of value, in a suitable solvent and the auxiliary base form at least one separate nonaqueous phase; and d) removal by distillation of at least part of any solvent present from the at least one nonaqueous phase obtained in step c), to form two nonmiscible liquid phases.

摘要翻译： 通过至少一种非极性胺作为辅助碱从反应混合物中除去酸的方法，该方法包括至少一种值得微溶于水的产物，其包括：a）使辅助基质与酸与形成物反应 的盐 b）使步骤a）中形成的盐与另外的碱反应，其另外的碱可以通过辅助碱的释放与酸接触，并与待辅助的酸结合，形成非常容易溶于水的盐; c）用水或水性介质萃取步骤b）中得到的混合物，其中另外碱的盐溶解在水相中，并且将有价值的产物或产品的溶液在合适的溶剂中溶解， 辅助碱形成至少一个分离的非水相; 和d）通过蒸馏除去存在于步骤c）中获得的至少一种非水相中的任何溶剂的至少一部分，以形成两个不可混溶的液相。

公开(公告)号：US07495130B2

公开(公告)日：2009-02-24

申请号：US10564855

申请日：2004-07-14

申请人： Matthias Maase ,  Gerhard Bertlein ,  Holger Ganz ,  Matthias Dust

发明人： Matthias Maase ,  Gerhard Bertlein ,  Holger Ganz ,  Matthias Dust

IPC分类号： C07C51/58 ,  C07C63/10

CPC分类号： C07C51/58 ,  C07C63/04

摘要： A process for preparing mono- or poly-C1-C20-alkyl- and/or -halogen-substituted arylcarbonyl chlorides (I), by, in a first stage, reacting a mono- or poly-C1-C20-alkyl- and/or -halogen-substituted aromatic (II) with CCl4 in the presence of a Friedel-Crafts catalyst to give the corresponding mono- or poly-C1-C20-alkyl- and/or -halogen-substituted trichloromethylated aromatic (III),and, in a second stage, treating the trichloromethylated aromatic (III) with water or a protic acid in the presence of a catalyst to obtain the arylcarbonyl chloride (I).In a particularly preferred embodiment, the trichloromethylated aromatic (III) is not isolated as an intermediate and is used in the second stage dissolved in the solvent of the first stage.

摘要翻译： 一种制备单-Ca-C20烷基和/或卤素取代的芳基羰基氯化物（I）的方法，在第一阶段中，使单 - 或多-C1-C20烷基 - 和/ 或 - 卤素取代的芳族（II）与CCl 4在Friedel-Crafts催化剂存在下反应，得到相应的单或多C1-C20烷基 - 和/或 - 卤素取代的三氯甲基化芳族（III） 在第二阶段中，在催化剂存在下用水或质子酸处理三氯甲基化芳族化合物（III），得到芳基羰基氯（I）。 在特别优选的实施方案中，三氯甲基化芳族（III）不作为中间体分离，并且用于溶解在第一阶段的溶剂中的第二阶段。

公开(公告)号：US20060178530A1

公开(公告)日：2006-08-10

申请号：US10564855

申请日：2004-07-14

申请人： Matthias Maase ,  Gerhard Bertlein ,  Holger Ganz ,  Matthias Dust

发明人： Matthias Maase ,  Gerhard Bertlein ,  Holger Ganz ,  Matthias Dust

IPC分类号： C07C51/58

CPC分类号： C07C51/58 ,  C07C63/04

摘要： A process for preparing mono- or poly-C1-C20-alkyl- and/or -halogen-substituted arylcarbonyl chlorides (I), by, in a first stage, reacting a mono- or poly-C1-C20-alkyl- and/or -halogen-substituted aromatic (II) with CCl4 in the presence of a Friedel-Crafts catalyst to give the corresponding mono- or poly-C1-C20-alkyl- and/or -halogen-substituted trichloromethylated aromatic (III), and, in a second stage, treating the trichloromethylated aromatic (III) with water or a protic acid in the presence of a catalyst to obtain the arylcarbonyl chloride (I). In a particularly preferred embodiment, the trichloromethylated aromatic (III) is not isolated as an intermediate and is used in the second stage dissolved in the solvent of the first stage.

摘要翻译： 通过在第一阶段中制备单或多-C 1 -C 20 - 烷基 - 和/或 - 卤素取代的芳基羰基氯（I）的方法 ，使单-CA或多-C 1 -C 20 - 烷基 - 和/或 - 卤素取代的芳族（II）与CCl 4