公开(公告)号：US09920045B2

公开(公告)日：2018-03-20

申请号：US15344372

申请日：2016-11-04

申请人： Omeros Corporation

发明人： Ekaterina Albert ,  Jennifer Leigh Nelson ,  Christopher Scott Seadeek ,  Karl Reineke ,  Marco Jonas ,  Suba Iyer ,  Xufeng Sun ,  Neil S. Cutshall ,  Jennifer Lynn Gage ,  Thomas L. Little ,  Wayne Douglas Luke ,  Elisabeth C. A. Brot ,  Michael James McDermott

IPC分类号： C07D417/10

CPC分类号： C07D417/10 ,  C07B2200/13

摘要： The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.

公开(公告)号：US20170166559A1

公开(公告)日：2017-06-15

申请号：US15344372

申请日：2016-11-04

申请人： Omeros Corporation

发明人： Ekaterina Albert ,  Jennifer Leigh Nelson ,  Christopher Scott Seadeek ,  Karl Reineke ,  Marco Jonas ,  Suba Iyer ,  Xufeng Sun ,  Neil S. Cutshall ,  Jennifer Lynn Gage ,  Thomas L. Little ,  Wayne Douglas Luke ,  Elisabeth C. A. Brot ,  Michael James McDermott

IPC分类号： C07D417/10

CPC分类号： C07D417/10 ,  C07B2200/13

摘要： The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.