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公开(公告)号：US20240317682A1
公开(公告)日：2024-09-26
申请号：US18680563
申请日：2024-05-31
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung
IPC: C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
CPC classification number: C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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公开(公告)号：US20240307537A1
公开(公告)日：2024-09-19
申请号：US18451632
申请日：2023-08-17
Applicant: Omeros Corporation
Inventor： Michael Cicirelli , Neil S. Cutshall , Gregory A. Demopulos , George A. Gaitanaris , Marc A. Gavin , Alexander Gragerov , Thomas L. Little , Rene Onrust
IPC: A61K39/00 , A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4409 , A61K31/473 , A61K31/495 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/55 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/28 , G01N33/574
CPC classification number: A61K39/4643 , A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4409 , A61K31/473 , A61K31/495 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/55 , A61K39/39558 , A61K45/06 , A61P35/00 , C07K16/28 , G01N33/57488 , A61K2039/505 , A61K2039/545 , C07K2317/76
Abstract: This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).
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公开(公告)号：US20130196994A1
公开(公告)日：2013-08-01
申请号：US13679818
申请日：2012-11-16
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Thomas Neil Wheeler , Thomas L. Little
IPC: A61K31/5377 , A61K31/422 , A61K31/454 , A61K31/421 , A61K31/4709 , A61K31/4245 , A61K31/497 , A61K31/433 , A61K31/4155 , A61K31/341 , A61K31/4545 , A61K31/4192 , A61K31/4196 , A61K31/415 , A61K31/427
CPC classification number: C07D307/46 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , C07D231/12 , C07D285/08 , C07D285/12 , C07D307/34 , C07D307/40 , C07D401/04 , C07D405/10 , C07D407/10 , C07D413/10 , C07D417/10 , Y02A50/465
Abstract: Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
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公开(公告)号：US20240228499A1
公开(公告)日：2024-07-11
申请号：US18523642
申请日：2023-11-29
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert von Specht , Jennifer Tsoung , Sudheer Babu Vaddela , Connor Weidle
IPC: C07D487/04 , A61K31/519 , A61K31/5377 , C07D519/00
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D519/00
Abstract: The disclosure provides synthetic compositions useful as inhibitors of mannan-binding lectin-associated serine protease-2 (MASP-2), including compositions that selectively inhibit MASP-2 over thrombin, as well as methods for the manufacture and use thereof.
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公开(公告)号：US09920045B2
公开(公告)日：2018-03-20
申请号：US15344372
申请日：2016-11-04
Applicant: Omeros Corporation
Inventor： Ekaterina Albert , Jennifer Leigh Nelson , Christopher Scott Seadeek , Karl Reineke , Marco Jonas , Suba Iyer , Xufeng Sun , Neil S. Cutshall , Jennifer Lynn Gage , Thomas L. Little , Wayne Douglas Luke , Elisabeth C. A. Brot , Michael James McDermott
IPC: C07D417/10
CPC classification number: C07D417/10 , C07B2200/13
Abstract: The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.
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Patent Agency Ranking
公开(公告)号：US20170152238A1
公开(公告)日：2017-06-01
申请号：US15229020
申请日：2016-08-04
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Thomas Neil Wheeler , Thomas L. Little
IPC: C07D307/46 , C07D417/10 , C07D407/10 , C07D413/10 , C07D405/10
CPC classification number: C07D307/46 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , C07D231/12 , C07D285/08 , C07D285/12 , C07D307/34 , C07D307/40 , C07D401/04 , C07D405/10 , C07D407/10 , C07D413/10 , C07D417/10 , Y02A50/465
Abstract: Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
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公开(公告)号：US09102643B2
公开(公告)日：2015-08-11
申请号：US14177952
申请日：2014-02-11
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Thomas Neil Wheeler , Thomas L. Little
IPC: C07D307/34 , C07D307/40 , C07D231/12 , C07D401/04 , C07D405/10 , C07D413/10 , C07D417/10 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , C07D285/12
CPC classification number: C07D307/46 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , C07D231/12 , C07D285/08 , C07D285/12 , C07D307/34 , C07D307/40 , C07D401/04 , C07D405/10 , C07D407/10 , C07D413/10 , C07D417/10 , Y02A50/465
Abstract: Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
Abstract translation: 公开了抑制PDE10的化合物，其可用于治疗各种病症，包括（但不限于）精神病性，焦虑症，运动障碍和/或神经障碍，例如帕金森病，亨廷顿氏病，阿尔茨海默病，脑炎，恐惧症 ，癫痫，失语症，贝尔麻痹，脑性麻痹，睡眠障碍，疼痛，图雷特综合征，精神分裂症，妄想症，药物诱发的精神病，恐慌和强迫症。 还提供了化合物的药学上可接受的盐，立体异构体，溶剂合物和前药。 还公开了含有与药学上可接受的载体组合的化合物的组合物，以及涉及其在需要其的温血动物中用于抑制PDE10的方法。
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公开(公告)号：US20140228581A1
公开(公告)日：2014-08-14
申请号：US14177952
申请日：2014-02-11
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Thomas Neil Wheeler , Thomas L. Little
IPC: C07D307/40 , C07D285/12
CPC classification number: C07D307/46 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , C07D231/12 , C07D285/08 , C07D285/12 , C07D307/34 , C07D307/40 , C07D401/04 , C07D405/10 , C07D407/10 , C07D413/10 , C07D417/10 , Y02A50/465
Abstract: Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
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公开(公告)号：US08685975B2
公开(公告)日：2014-04-01
申请号：US13679818
申请日：2012-11-16
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Thomas Neil Wheeler , Thomas L. Little
IPC: A61K31/5377 , A61K31/497 , A61K31/4709 , A61K31/4545 , A61K31/454 , A61K31/4535 , A61K31/4525 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/443 , A61K31/426 , A61K31/4245 , A61K31/421 , A61K31/4196 , A61K31/4192 , A61K31/4164 , A61K31/4155 , A61K31/34 , C07D417/10 , C07D413/14 , C07D405/06 , C07D407/14 , C07D407/10 , C07D407/06 , C07D307/46 , C07D263/32 , C07D231/12
CPC classification number: C07D307/46 , A61K31/341 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/5377 , C07D231/12 , C07D285/08 , C07D285/12 , C07D307/34 , C07D307/40 , C07D401/04 , C07D405/10 , C07D407/10 , C07D413/10 , C07D417/10 , Y02A50/465
Abstract: Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.
Abstract translation: 公开了抑制PDE10的化合物，其可用于治疗各种病症，包括（但不限于）精神病性，焦虑症，运动障碍和/或神经障碍，例如帕金森病，亨廷顿氏病，阿尔茨海默病，脑炎，恐惧症 ，癫痫，失语症，贝尔麻痹，脑性麻痹，睡眠障碍，疼痛，图雷特综合征，精神分裂症，妄想症，药物诱发的精神病，恐慌和强迫症。 还提供了化合物的药学上可接受的盐，立体异构体，溶剂合物和前药。 还公开了含有与药学上可接受的载体组合的化合物的组合物，以及涉及其在需要其的温血动物中用于抑制PDE10的方法。
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公开(公告)号：US12030853B2
公开(公告)日：2024-07-09
申请号：US17112873
申请日：2020-12-04
Applicant: Omeros Corporation
Inventor： Neil S. Cutshall , Jennifer Lynn Gage , Sara Rebecca Goldstein , Do Yeon Kwon , Thomas L. Little , Markus Metz , Peter Kurt Nollert Von Specht , Jennifer Tsoung
IPC: C07D207/16 , A61K31/40 , C07D403/04 , C07D413/04 , C07D471/04
CPC classification number: C07D207/16 , C07D403/04 , C07D413/04 , C07D471/04
Abstract: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds, and methods of making and using such compounds.
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