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公开(公告)号：US20160326259A1
公开(公告)日：2016-11-10
申请号：US15003322
申请日：2016-01-21
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Chartes Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/30 , A61K31/7068 , A61K31/337 , A61K39/395 , A61K45/06
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
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公开(公告)号：US09273139B2
公开(公告)日：2016-03-01
申请号：US13800454
申请日：2013-03-13
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/28 , C12P21/08 , A61K39/395 , C07K16/30 , A61K31/00 , A61K45/06 , G01N33/50 , A61K39/00
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。
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公开(公告)号：US20150232554A1
公开(公告)日：2015-08-20
申请号：US14605560
申请日：2015-01-26
发明人： Austin L. GURNEY , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。
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公开(公告)号：US09573998B2
公开(公告)日：2017-02-21
申请号：US14605560
申请日：2015-01-26
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。
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公开(公告)号：US20130295106A1
公开(公告)日：2013-11-07
申请号：US13800801
申请日：2013-03-13
发明人： Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： G01N33/5011 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K14/4702 , C07K14/71 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N2333/726 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and other polypeptides, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided. Screening methods are also provided.
摘要翻译： 提供了与人类卷曲受体结合的新型抗癌剂，包括但不限于抗体和其他多肽。 还鉴定了适合作为抗癌剂靶标的人类卷曲受体中的新表位。 进一步提供使用试剂或抗体的方法，例如使用该试剂或抗体抑制Wnt信号传导和/或抑制肿瘤生长的方法。 还提供筛选方法。
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公开(公告)号：US20130266569A1
公开(公告)日：2013-10-10
申请号：US13826103
申请日：2013-03-14
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
摘要翻译： 描述了特异性结合人DLL4的细胞外结构域并影响包含癌干细胞的肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，包括施用治疗有效量的抗DLL4抗体。
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公开(公告)号：US09228020B2
公开(公告)日：2016-01-05
申请号：US13826103
申请日：2013-03-14
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06 , A61K39/00
CPC分类号： A61K39/39558 , A61K31/4745 , A61K31/513 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3046 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , A61K2300/00
摘要： An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described. Also described is a method of treating cancer comprising administering a therapeutically effective amount of an anti-DLL4 antibody.
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公开(公告)号：US20140199312A1
公开(公告)日：2014-07-17
申请号：US14148669
申请日：2014-01-06
IPC分类号： C07K16/28 , A61K45/06 , A61K39/395
CPC分类号： C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2851 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2319/30 , C07K2319/32 , A61K2300/00
摘要： The present invention relates to DDR1 binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind to an extracellular domain of DDR1 and modulate DDR1 activity. The present invention further provides methods of using agents that modulate the activity of DDR1, such as antibodies that specifically bind DDR1, to reduce the tumorigenicity of tumors comprising cancer stem cells by reducing the frequency or number of cancer stem cells in the tumor. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
摘要翻译： 本发明涉及DDR1结合剂和使用该药物治疗诸如癌症的疾病的方法。 本发明提供特异性结合DDR1细胞外结构域并调节DDR1活性的抗体。 本发明还提供使用调节DDR1的活性的试剂的方法，例如特异性结合DDR1的抗体，通过降低肿瘤中癌症干细胞的频率或数量来降低包含癌症干细胞的肿瘤的致瘤性。 还描述了治疗癌症的方法，其包括向具有肿瘤或癌症的患者施用治疗有效量的本发明的药剂或抗体。
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公开(公告)号：US20130295105A1
公开(公告)日：2013-11-07
申请号：US13800454
申请日：2013-03-13
发明人： Austin L. GURNEY , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/28 , A61K31/00 , A61K31/337 , A61K31/7068 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5011 , A61K2300/00
摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
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公开(公告)号：US20180222997A1
公开(公告)日：2018-08-09
申请号：US15817998
申请日：2017-11-20
CPC分类号： C07K16/30 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K16/468 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： An isolated antibody that specifically binds to an extracellular domain of two or more human FZD receptors and inhibits growth of tumor cells is described. Also described is a method of treating cancer comprising administering an antibody of the present disclosure in an amount effective to inhibit tumor cell growth.
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