公开(公告)号：US20160326259A1

公开(公告)日：2016-11-10

申请号：US15003322

申请日：2016-01-21

申请人： OncoMed Pharmaceuticals, Inc.

发明人： Austin L. Gurney ,  Aaron Ken Sato ,  Fumiko Takada Axelrod ,  Timothy Chartes Hoey ,  Sanjeev H. Satyal ,  Satyajit Sujit Kumar Mitra

IPC分类号： C07K16/30 ,  A61K31/7068 ,  A61K31/337 ,  A61K39/395 ,  A61K45/06

CPC分类号： C07K16/28 ,  A61K31/00 ,  A61K31/337 ,  A61K31/7068 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  G01N33/5011 ,  A61K2300/00

摘要： Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.