公开(公告)号：US20200339569A1

公开(公告)日：2020-10-29

申请号：US16768931

申请日：2018-12-05

Applicant: Oryzon Genomics, S.A.

Inventor： Elena CARCELLER GONZÁLEZ ,  Alberto ORTEGA MUÑOZ ,  Jorge SALAS SOLANA

IPC: C07D471/04 ,  C07D413/14

Abstract: The invention relates to compounds of Formula (I) as described herein, useful as histone deacetylase 6 (HDAC6) inhibitors. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in therapy.

公开(公告)号：US20220389478A1

公开(公告)日：2022-12-08

申请号：US17644604

申请日：2021-12-16

Applicant: Oryzon Genomics S.A.

Inventor： Elena CARCELLER GONZÁLEZ ,  Tamara MAES ,  Cristina MASCARO CRUSAT ,  Alberto ORTEGA MUÑOZ

IPC: C12Q1/26 ,  C07D495/04 ,  G01N33/58

Abstract: The invention relates to methods to determine KDM1A target engagement and chemoprobes useful therefor. In particular, the invention relates to non-peptidic KDM1A chemoprobes carrying a tag or label that can be used to assess KDM1A target engagement in cells and tissues. These chemoprobes can also be used to identify KDM1A interacting factors and analyze expression levels of KDM1A.

公开(公告)号：US20190085372A1

公开(公告)日：2019-03-21

申请号：US16085024

申请日：2017-03-16

Applicant: Oryzon Genomics S.A.

Inventor： Elena CARCELLER GONZÁLEZ ,  Tamara MAES ,  Cristina MASCARO CRUSAT ,  Alberto ORTEGA MUN0Z

IPC: C12Q1/26 ,  C07D495/04

Abstract: The invention relates to methods to determine KDM1A target engagement and chemoprobes useful therefor. In particular, the invention relates to non-peptidic KDM1A chemoprobes carrying a tag or label that can be used to assess KDM1A target engagement in cells and tissues. These chemoprobes can also be used to identify KDM1A interacting factors and analyze expression levels of KDM1A.

公开(公告)号：US20230026909A1

公开(公告)日：2023-01-26

申请号：US17650561

申请日：2022-02-10

Applicant: Oryzon Genomics, S.A.

Inventor： Elena CARCELLER GONZÁLEZ ,  Alberto ORTEGA MUÑOZ ,  Jorge SALAS SOLANA

IPC: C07D471/04 ,  C07D413/14

Abstract: The invention relates to compounds of Formula (I) as described herein, useful as histone deacetylase 6 (HDAC6) inhibitors. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in therapy.

公开(公告)号：US20220298156A1

公开(公告)日：2022-09-22

申请号：US17596048

申请日：2020-06-05

Applicant: ORYZON GENOMICS, S.A.

Inventor： Elena CARCELLER GONZÁLEZ ,  Alberto ORTEGA MUÑOZ ,  Jorge SALAS SOLANA

IPC: C07D471/04

Abstract: The invention relates to compounds as described herein, useful as histone deacetylase 6 (HDAC6) inhibitors. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in therapy.