公开(公告)号：US20230194472A1

公开(公告)日：2023-06-22

申请号：US17605917

申请日：2020-04-24

Applicant: Osaka University

Inventor： Masateru Taniguchi ,  Hideshi Ishii ,  Takahito Ohshiro ,  Masamitsu Konno

IPC: G01N27/62 ,  C12Q1/6886

CPC classification number: G01N27/62 ,  C12Q1/6886

Abstract: The present disclosure provides a method for analyzing a microRNA using a tunneling current. The present disclosure provides a method for identifying the base sequence and/or modification state of a microRNA using a tunneling current, and a system and a program to be used in the method. Furthermore, the present disclosure provides a method for analyzing the conditions of a subject, said method comprising determining the base sequence and/or modification state of a microRNA using a tunneling current. For example, methylation modification can be analyzed thereby.

公开(公告)号：US11707530B2

公开(公告)日：2023-07-25

申请号：US16326657

申请日：2017-08-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC: A61K47/64 ,  A61K49/14

CPC classification number: A61K47/6455 ,  A61K49/146

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.

公开(公告)号：US20230175066A1

公开(公告)日：2023-06-08

申请号：US16971604

申请日：2019-02-21

Applicant: OSAKA UNIVERSITY

Inventor： Hideshi Ishii ,  Masamitsu Konno ,  Masaki Mori

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/178

Abstract: The present application provides a novel method for analyzing a biological condition or a medical condition. It is now found that information about the modification of RNA can be used for the analysis of a biological condition or a medical condition. On the basis of this finding, the present invention provides a novel method for analyzing a biological condition or a medical condition. According to the present invention, it becomes possible to analyze various biological conditions or medical conditions including diseases, and it also becomes possible to satisfactorily predict cancer (e.g., pancreatic cancer, colorectal cancer, stomach cancer) in an early stage.

公开(公告)号：US20210308271A1

公开(公告)日：2021-10-07

申请号：US16326657

申请日：2017-08-17

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  OSAKA UNIVERSITY

Inventor： Nobuhiro Nishiyama ,  Hiroyasu Takemoto ,  Takahiro Nomoto ,  Keishiro Tomoda ,  Makoto Matsui ,  Naoki Yamada ,  Yuto Honda ,  Hideshi Ishii ,  Masaki Mori ,  Masamitsu Konno

IPC: A61K47/64 ,  A61K49/14

Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.