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公开(公告)号：US10106578B2
公开(公告)日：2018-10-23
申请号：US15422850
申请日：2017-02-02
发明人： Wei Yang , Yi-Qun Shi
摘要： Melanocortin receptor-specific linear peptides of the formula Z-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Y (VI) or a pharmaceutically acceptable salt thereof, where Z, Y, Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, and Xaa6 are as defined in the specification, compositions and formulations including peptides of the foregoing formula or salts thereof, and pharmaceutical compositions for preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
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公开(公告)号：US20170008931A1
公开(公告)日：2017-01-12
申请号：US15268761
申请日：2016-09-19
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/56
CPC分类号： C07K7/56 , A61K31/407 , A61K38/00 , C07K7/54 , C07K14/68
摘要： Melanocortin receptor-specific cyclic hexapeptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claims, compositions and formulations including the hexapeptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如权利要求中所定义，组合物和制剂包括前述式的六肽或其盐，以及预防，改善或治疗黑皮质素-1 受体介导或反应性疾病，适应症，病症和综合征。
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3.发明授权Melanocortin receptor-specific peptides for treatment of female sexual dysfunction 有权用于治疗女性性功能障碍的黑皮质素受体特异性肽公开(公告)号：US08729224B2
公开(公告)日：2014-05-20
申请号：US13910506
申请日：2013-06-05
发明人： Yi-Qun Shi , Shubh D. Sharma , Wei Yang , Xin Chen
IPC分类号： A61K38/12
CPC分类号： C07K7/56 , A61K38/00 , A61K38/12 , A61K45/06 , C07K14/685
摘要： Methods for use of a melanocortin receptor agonist cyclic peptide of the formula where R, x and y are as defined in the specification, and compositions and formulations including the peptide of the foregoing formula, for preventing, ameliorating or treating female sexual dysfunction.
摘要翻译： 使用下式的黑皮质素受体激动剂环肽的方法，其中R，x和y如说明书中所定义，以及包含前述式的肽的组合物和制剂，用于预防，改善或治疗女性性功能障碍。
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公开(公告)号：US09447148B2
公开(公告)日：2016-09-20
申请号：US14514472
申请日：2014-10-15
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/54 , C07K7/56 , C07K14/68 , A61K31/407 , A61K38/00
CPC分类号： C07K7/56 , A61K31/407 , A61K38/00 , C07K7/54 , C07K14/68
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
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公开(公告)号：US11286280B2
公开(公告)日：2022-03-29
申请号：US16927347
申请日：2020-07-13
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/56 , C07K14/68 , A61K31/407 , C07K7/54 , A61K38/00
摘要： Methods preventing, ameliorating or treating cytokine storm or inflammatory disease, indications, conditions and syndromes by administration of a therapeutically effective amount of a melanocortin-1 receptor-specific cyclic peptide or pharmaceutically acceptable salt thereof.
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公开(公告)号：US20200339631A1
公开(公告)日：2020-10-29
申请号：US16927347
申请日：2020-07-13
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/56 , C07K14/68 , A61K31/407 , C07K7/54
摘要： Methods preventing, ameliorating or treating cytokine storm or inflammatory disease, indications, conditions and syndromes by administration of a therapeutically effective amount of a melanocortin-1 receptor-specific cyclic peptide or pharmaceutically acceptable salt thereof.
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公开(公告)号：US20190216887A1
公开(公告)日：2019-07-18
申请号：US16245735
申请日：2019-01-11
发明人： Yi-qun Shi , Shubh D Sharma , John H Dodd , Wei Yang , Xin Chen
CPC分类号： A61K38/12 , A61K33/16 , A61K38/00 , A61P5/06 , C07K5/1024 , C07K7/56 , C07K7/64 , C07K14/685 , Y02A50/401
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R3, R4, R9 and R10 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes.
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公开(公告)号：US20170145056A1
公开(公告)日：2017-05-25
申请号：US15422850
申请日：2017-02-02
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , C07K14/68 , Y02A50/401
摘要： Melanocortin receptor-specific linear peptides of the formula Z-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Y (VI) or a pharmaceutically acceptable salt thereof, where Z, Y, Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, and Xaa6 are as defined in the specification, compositions and formulations including peptides of the foregoing formula or salts thereof, and pharmaceutical compositions for preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.
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公开(公告)号：US10711039B2
公开(公告)日：2020-07-14
申请号：US15873180
申请日：2018-01-17
发明人： Wei Yang , Yi-Qun Shi
IPC分类号： C07K7/56 , C07K14/68 , A61K31/407 , C07K7/54 , A61K38/00
摘要： Melanocortin receptor-specific peptides with a C-terminal naphthylalanine of the formula: where R4, R7, R9, R11, R18, R20, R21a, R21b, R21c and R22 are as defined in the claims, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin receptor-mediated or responsive diseases, indications, conditions and syndromes.
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公开(公告)号：US10179804B2
公开(公告)日：2019-01-15
申请号：US15214845
申请日：2016-07-20
发明人： Yi-qun Shi , Shubh D. Sharma , John H. Dodd , Wei Yang
摘要： Melanocortin receptor-specific cyclic peptides of the formula where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and z are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes.
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