公开(公告)号：US20160194400A1

公开(公告)日：2016-07-07

申请号：US14916943

申请日：2014-09-05

Applicant: UNIVERSITY OF MIYAZAKI ,  FUJITA HEALTH UNIVERSITY ,  PERSEUS PROTEOMICS INC.

Inventor： Kazuhiro MORISHITA ,  Kazuko KANEDA ,  Yoshikazu KUROSAWA ,  Gene KUROSAWA ,  Katsuyuki MITOMO ,  Katsushi KOUDA ,  Yoshinori UKAI

IPC: C07K16/28 ,  A61K31/365 ,  A61K31/704 ,  A61K39/395 ,  A61K31/7068

CPC classification number: C07K16/2839 ,  A61K31/365 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C12N2510/02 ,  A61K2300/00

Abstract: It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.

Abstract translation: 本发明的目的是提供一种抗ITGA6 / B4人抗体，其特异性地识别在细胞膜上表达的ITGA6B4复合物并且抑制ITGA6B4复合物与层粘连蛋白的粘附，以便抑制癌细胞对 也能够显着提高抗癌剂对抗癌剂抗性菌株的效果。 本发明提供抗整联蛋白A6B4的抗体，其中所述抗体特异性识别人整联蛋白A6B4复合物并抑制细胞间粘附。

公开(公告)号：US20140004536A1

公开(公告)日：2014-01-02

申请号：US13891652

申请日：2013-05-10

Applicant: PERSEUS PROTEOMICS INC. ,  FUJITA HEALTH UNIVERSITY

Inventor： Yoshikazu KUROSAWA ,  Maiko KUROSAWA ,  Gene KUROSAWA

IPC: C07K16/30 ,  G01N33/68

CPC classification number: C07K16/30 ,  C07K16/28 ,  C07K2317/622 ,  G01N33/6893

Abstract: To provide a method for detecting cellular DNA damage by specifically recognizing molecules responsive to DNA strand breaks. A method for detecting DNA damage in cells, which comprises administering in vivo, to cells, an antibody against a cell membrane surface antigen that is expressed in cells undergoing DNA strand breaks to a greater extent than in cells not undergoing DNA strand breaks in an environment that causes DNA damage, and analyzing the expression status of the cell membrane surface antigen.

Abstract translation: 提供通过特异性识别对DNA链断裂有反应的分子来检测细胞DNA损伤的方法。 一种用于检测细胞中DNA损伤的方法，其包括在体内向细胞施用针对细胞膜表面抗原的抗体，其在经历DNA链断裂的细胞中表达的程度大于在环境中不经历DNA链断裂的细胞中 导致DNA损伤，并分析细胞膜表面抗原的表达状态。

公开(公告)号：US20140235833A1

公开(公告)日：2014-08-21

申请号：US14265416

申请日：2014-04-30

Applicant: Fujita Health University

Inventor： Atsushi SUGIOKA ,  Gene KUROSAWA ,  Mariko SUMITOMO ,  Yoshikazu KUROSAWA

IPC: C07K16/30

CPC classification number: C07K16/30 ,  C07K16/005 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2896 ,  C07K16/303 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57492 ,  G01N33/6854

Abstract: The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies. The invention further relates to transformants comprising said nucleic acids or vectors.

Abstract translation: 本发明涉及针对HER1的分离抗体，针对CD147的分离抗体，针对CD73的分离抗体和针对EpCAM的分离抗体; 包括所述抗体的试剂和组合物; 和所述试剂，组合物和抗体的用途。 本发明还涉及表达所述抗体的核酸和载体。 本发明还涉及包含所述核酸或载体的转化体。