公开(公告)号：US11110158B2

公开(公告)日：2021-09-07

申请号：US16058257

申请日：2018-08-08

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Helen Kim Cho ,  Michael Robert Dermyer ,  Karin Ute Jooss ,  Brian Gregory Pierce ,  Joyce Tsi Tan ,  Van To Tsai ,  James Richard Merson

IPC分类号： A61K39/00 ,  C07K14/47 ,  C12N9/48 ,  A61K39/39 ,  A61K39/395 ,  A61K31/404 ,  C12N9/64 ,  A61K9/00 ,  A61K31/7088 ,  C07K16/28 ,  C07K16/30

摘要： The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

公开(公告)号：US20190016775A1

公开(公告)日：2019-01-17

申请号：US16029878

申请日：2018-07-09

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Helen Kim Cho ,  Paul Jason Cockle ,  Derek John Falconer ,  Siradanahalli Guru ,  Marianne Marcela Andrea Martinic

IPC分类号： C07K14/705 ,  C12N9/12

摘要： The present disclosure provides: (a) isolated immunogenic CEA polypeptides; (b) isolated nucleic acid molecules encoding (i) an immunogenic CEA polypeptide, (ii) an immunogenic CEA polypeptide and an immunogenic MUC1 polypeptide, (iii) an immunogenic CEA polypeptide and an immunogenic TERT polypeptide, or (iv) an immunogenic CEA polypeptide, an immunogenic MUC1 polypeptide, and an immunogenic TERT polypeptide; (c) compositions comprising an isolated nucleic acid molecule; and (d) methods relating to uses of the immunogenic CEA polypeptides, nucleic acid molecules, and compositions.

公开(公告)号：US20150246106A1

公开(公告)日：2015-09-03

申请号：US14657302

申请日：2015-03-13

申请人： Pfizer Inc

发明人： Joseph John Binder ,  Helen Kim Cho ,  Michael Robert Dermyer ,  Karin Ute Jooss ,  Brian Gregory Pierce ,  Joyce Tsi Tan ,  Van To Tsai

IPC分类号： A61K39/00 ,  C12N9/48 ,  C07K14/47 ,  C12N9/64 ,  A61K39/395 ,  A61K31/404

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K31/404 ,  A61K31/7088 ,  A61K39/39 ,  A61K39/3955 ,  A61K2039/53 ,  A61K2039/55561 ,  C07K14/4748 ,  C07K16/2818 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/76 ,  C12N9/485 ,  C12N9/6445 ,  C12Y304/17021

摘要： The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

摘要翻译： 本公开内容提供（a）分离的免疫原性PAA多肽; （b）编码免疫原性PAA多肽的分离的核酸分子; （c）包含免疫原性PAA多肽或编码免疫原性PAA多肽的分离的核酸分子的疫苗组合物; （d）与多肽，核酸分子和组合物的用途有关的方法; 和（e）基于疫苗的免疫治疗方案，其涉及将疫苗与免疫抑制细胞抑制剂和免疫效应细胞增强剂组合共同给药。

公开(公告)号：US20220323558A1

公开(公告)日：2022-10-13

申请号：US17319395

申请日：2021-05-13

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Paul Jason Cockle ,  Derek John Falconer ,  Siradanahalli Guru ,  Karin Ute Jooss ,  Marianne Marcela Andrea Martinic ,  Kenneth Nelson Wills ,  Helen Kim Cho

IPC分类号： A61K39/00 ,  A61K48/00

摘要： The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.

公开(公告)号：US20190142918A1

公开(公告)日：2019-05-16

申请号：US16252239

申请日：2019-01-18

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Paul Jason Cockle ,  Derek John Falconer ,  Siradanahalli Guru ,  Karin Ute Jooss ,  Marianne Marcela Andrea Martinic ,  Kenneth Nelson Wills ,  Helen Kim Cho

IPC分类号： A61K39/00 ,  A61K48/00

摘要： The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.

公开(公告)号：US10251944B2

公开(公告)日：2019-04-09

申请号：US15407890

申请日：2017-01-17

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Paul Jason Cockle ,  Derek John Falconer ,  Siradanahalli Guru ,  Karin Ute Jooss ,  Marianne Marcela Andrea Martinic ,  Kenneth Nelson Wills ,  Helen Kim Cho

IPC分类号： A61K39/00 ,  A61K31/711 ,  C12N15/12 ,  C12N15/62 ,  A61K48/00

摘要： The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.

公开(公告)号：US20190038728A1

公开(公告)日：2019-02-07

申请号：US16058257

申请日：2018-08-08

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Helen Kim Cho ,  Michael Robert Dermyer ,  Karin Ute Jooss ,  Brian Gregory Pierce ,  Joyce Tsi Tan ,  Van To Tsai ,  James Richard Merson

IPC分类号： A61K39/00 ,  A61K9/00 ,  C12N9/48 ,  C12N9/64 ,  A61K31/404 ,  A61K31/7088 ,  A61K39/39 ,  C07K16/30 ,  C07K16/28 ,  C07K14/47 ,  A61K39/395

摘要： The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

公开(公告)号：US11058753B2

公开(公告)日：2021-07-13

申请号：US16252239

申请日：2019-01-18

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Paul Jason Cockle ,  Derek John Falconer ,  Siradanahalli Guru ,  Karin Ute Jooss ,  Marianne Marcela Andrea Martinic ,  Kenneth Nelson Wills ,  Helen Kim Cho

IPC分类号： A61K39/00 ,  C12N15/62 ,  A61K48/00 ,  A61K31/711

摘要： The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.

公开(公告)号：US20170202938A1

公开(公告)日：2017-07-20

申请号：US15407890

申请日：2017-01-17

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Paul Jason Cockle ,  Derek John Falconer ,  Siradanahalli Guru ,  Karin Ute Jooss ,  Marianne Marcela Andrea Martinic ,  Kenneth Nelson Wills ,  Helen Kim Cho

IPC分类号： A61K39/00

CPC分类号： A61K39/0011 ,  A61K2039/53 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/585 ,  A61K2039/70

摘要： The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.

公开(公告)号：US09468672B2

公开(公告)日：2016-10-18

申请号：US14657302

申请日：2015-03-13

申请人： Pfizer Inc

发明人： Joseph John Binder ,  Helen Kim Cho ,  Michael Robert Dermyer ,  Karin Ute Jooss ,  Brian Gregory Pierce ,  Joyce Tsi Tan ,  Van To Tsai

IPC分类号： A61K39/00 ,  C07H21/04 ,  A61K39/39 ,  A61K39/395 ,  C12N9/48 ,  A61K31/404 ,  C07K14/47 ,  C12N9/64

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K31/404 ,  A61K31/7088 ,  A61K39/39 ,  A61K39/3955 ,  A61K2039/53 ,  A61K2039/55561 ,  C07K14/4748 ,  C07K16/2818 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/76 ,  C12N9/485 ,  C12N9/6445 ,  C12Y304/17021

摘要： The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.