公开(公告)号：US20190038728A1

公开(公告)日：2019-02-07

申请号：US16058257

申请日：2018-08-08

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Helen Kim Cho ,  Michael Robert Dermyer ,  Karin Ute Jooss ,  Brian Gregory Pierce ,  Joyce Tsi Tan ,  Van To Tsai ,  James Richard Merson

IPC分类号： A61K39/00 ,  A61K9/00 ,  C12N9/48 ,  C12N9/64 ,  A61K31/404 ,  A61K31/7088 ,  A61K39/39 ,  C07K16/30 ,  C07K16/28 ,  C07K14/47 ,  A61K39/395

摘要： The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.

公开(公告)号：US11110158B2

公开(公告)日：2021-09-07

申请号：US16058257

申请日：2018-08-08

申请人： Pfizer Inc.

发明人： Joseph John Binder ,  Helen Kim Cho ,  Michael Robert Dermyer ,  Karin Ute Jooss ,  Brian Gregory Pierce ,  Joyce Tsi Tan ,  Van To Tsai ,  James Richard Merson

IPC分类号： A61K39/00 ,  C07K14/47 ,  C12N9/48 ,  A61K39/39 ,  A61K39/395 ,  A61K31/404 ,  C12N9/64 ,  A61K9/00 ,  A61K31/7088 ,  C07K16/28 ,  C07K16/30

摘要： The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.