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公开(公告)号：US11110158B2
公开(公告)日：2021-09-07
申请号：US16058257
申请日：2018-08-08
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Helen Kim Cho , Michael Robert Dermyer , Karin Ute Jooss , Brian Gregory Pierce , Joyce Tsi Tan , Van To Tsai , James Richard Merson
IPC: A61K39/00 , C07K14/47 , C12N9/48 , A61K39/39 , A61K39/395 , A61K31/404 , C12N9/64 , A61K9/00 , A61K31/7088 , C07K16/28 , C07K16/30
Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
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2.发明申请PROSTATE-ASSOCIATED ANTIGENS AND VACCINE-BASED IMMUNOTHERAPY REGIMENS 审中-公开PROSTATE相关抗原和基于疫苗的免疫治疗方案公开(公告)号：US20150246106A1
公开(公告)日：2015-09-03
申请号：US14657302
申请日：2015-03-13
Applicant: Pfizer Inc
Inventor： Joseph John Binder , Helen Kim Cho , Michael Robert Dermyer , Karin Ute Jooss , Brian Gregory Pierce , Joyce Tsi Tan , Van To Tsai
IPC: A61K39/00 , C12N9/48 , C07K14/47 , C12N9/64 , A61K39/395 , A61K31/404
CPC classification number: A61K39/0011 , A61K9/0019 , A61K31/404 , A61K31/7088 , A61K39/39 , A61K39/3955 , A61K2039/53 , A61K2039/55561 , C07K14/4748 , C07K16/2818 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/76 , C12N9/485 , C12N9/6445 , C12Y304/17021
Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
Abstract translation: 本公开内容提供（a）分离的免疫原性PAA多肽; （b）编码免疫原性PAA多肽的分离的核酸分子; （c）包含免疫原性PAA多肽或编码免疫原性PAA多肽的分离的核酸分子的疫苗组合物; （d）与多肽，核酸分子和组合物的用途有关的方法; 和（e）基于疫苗的免疫治疗方案，其涉及将疫苗与免疫抑制细胞抑制剂和免疫效应细胞增强剂组合共同给药。
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公开(公告)号：US20220323558A1
公开(公告)日：2022-10-13
申请号：US17319395
申请日：2021-05-13
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Paul Jason Cockle , Derek John Falconer , Siradanahalli Guru , Karin Ute Jooss , Marianne Marcela Andrea Martinic , Kenneth Nelson Wills , Helen Kim Cho
Abstract: The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
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公开(公告)号：US20190142918A1
公开(公告)日：2019-05-16
申请号：US16252239
申请日：2019-01-18
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Paul Jason Cockle , Derek John Falconer , Siradanahalli Guru , Karin Ute Jooss , Marianne Marcela Andrea Martinic , Kenneth Nelson Wills , Helen Kim Cho
Abstract: The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
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公开(公告)号：US10251944B2
公开(公告)日：2019-04-09
申请号：US15407890
申请日：2017-01-17
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Paul Jason Cockle , Derek John Falconer , Siradanahalli Guru , Karin Ute Jooss , Marianne Marcela Andrea Martinic , Kenneth Nelson Wills , Helen Kim Cho
IPC: A61K39/00 , A61K31/711 , C12N15/12 , C12N15/62 , A61K48/00
Abstract: The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
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Patent Agency Ranking
公开(公告)号：US20190038728A1
公开(公告)日：2019-02-07
申请号：US16058257
申请日：2018-08-08
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Helen Kim Cho , Michael Robert Dermyer , Karin Ute Jooss , Brian Gregory Pierce , Joyce Tsi Tan , Van To Tsai , James Richard Merson
IPC: A61K39/00 , A61K9/00 , C12N9/48 , C12N9/64 , A61K31/404 , A61K31/7088 , A61K39/39 , C07K16/30 , C07K16/28 , C07K14/47 , A61K39/395
Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
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公开(公告)号：US11058753B2
公开(公告)日：2021-07-13
申请号：US16252239
申请日：2019-01-18
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Paul Jason Cockle , Derek John Falconer , Siradanahalli Guru , Karin Ute Jooss , Marianne Marcela Andrea Martinic , Kenneth Nelson Wills , Helen Kim Cho
IPC: A61K39/00 , C12N15/62 , A61K48/00 , A61K31/711
Abstract: The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
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公开(公告)号：US20170202938A1
公开(公告)日：2017-07-20
申请号：US15407890
申请日：2017-01-17
Applicant: Pfizer Inc.
Inventor： Joseph John Binder , Paul Jason Cockle , Derek John Falconer , Siradanahalli Guru , Karin Ute Jooss , Marianne Marcela Andrea Martinic , Kenneth Nelson Wills , Helen Kim Cho
IPC: A61K39/00
CPC classification number: A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/575 , A61K2039/585 , A61K2039/70
Abstract: The present disclosure provides (i) isolated immunogenic TAA polypeptides (i.e., an immunogenic MUC1 polypeptides, an immunogenic MSLN polypeptides, and an immunogenic TERT polypeptides), (ii) isolated nucleic acid molecules encoding one or more immunogenic TAA polypeptides, (iii) compositions comprising an immunogenic TAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic TAA polypeptide, and (iv) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions.
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公开(公告)号：US09468672B2
公开(公告)日：2016-10-18
申请号：US14657302
申请日：2015-03-13
Applicant: Pfizer Inc
Inventor： Joseph John Binder , Helen Kim Cho , Michael Robert Dermyer , Karin Ute Jooss , Brian Gregory Pierce , Joyce Tsi Tan , Van To Tsai
IPC: A61K39/00 , C07H21/04 , A61K39/39 , A61K39/395 , C12N9/48 , A61K31/404 , C07K14/47 , C12N9/64
CPC classification number: A61K39/0011 , A61K9/0019 , A61K31/404 , A61K31/7088 , A61K39/39 , A61K39/3955 , A61K2039/53 , A61K2039/55561 , C07K14/4748 , C07K16/2818 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/76 , C12N9/485 , C12N9/6445 , C12Y304/17021
Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
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10.发明授权公开(公告)号：US09066898B2
公开(公告)日：2015-06-30
申请号：US13875162
申请日：2013-05-01
Applicant: PFIZER INC
Inventor： Joseph John Binder , Helen Kim Cho , Michael Robert Dermyer , Karin Ute Jooss , Brian Gregory Pierce , Joyce Tsi Tan , Van To Tsai
CPC classification number: A61K39/0011 , A61K9/0019 , A61K31/404 , A61K31/7088 , A61K39/39 , A61K39/3955 , A61K2039/53 , A61K2039/55561 , C07K14/4748 , C07K16/2818 , C07K16/3023 , C07K16/303 , C07K16/3069 , C07K2317/21 , C07K2317/76 , C12N9/485 , C12N9/6445 , C12Y304/17021
Abstract: The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.
Abstract translation: 本公开内容提供（a）分离的免疫原性PAA多肽; （b）编码免疫原性PAA多肽的分离的核酸分子; （c）包含免疫原性PAA多肽或编码免疫原性PAA多肽的分离的核酸分子的疫苗组合物; （d）与多肽，核酸分子和组合物的用途有关的方法; 和（e）基于疫苗的免疫治疗方案，其涉及将疫苗与免疫抑制细胞抑制剂和免疫效应细胞增强剂组合共同给药。
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