公开(公告)号：US20170275275A1

公开(公告)日：2017-09-28

申请号：US15310113

申请日：2015-05-29

Applicant: PFIZER INC.

Inventor： ALAN DANIEL BROWN ,  LYN HOWARD JONES ,  BRIAN EDWARD MARRON ,  DAVID JAMES RAWSON ,  THOMAS RYCKMANS ,  ROBERT IAN STORER ,  NIGEL ALAN SWAIN ,  CHRISTOPHER WILLIAM WEST

IPC: C07D417/14 ,  C07D285/08 ,  A61K31/4439 ,  C07D417/12 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  C07D285/08 ,  C07D417/12

Abstract: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I), or a pharmaceutically acceptable salt thereof, wherein X, R1, R2, R3a, R3b and R4 are as defined in the description. Nav1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

公开(公告)号：US20150322043A1

公开(公告)日：2015-11-12

申请号：US14705272

申请日：2015-05-06

Applicant: PFIZER INC

Inventor： SHARANJEET KAUR BAGAL ,  JINGRONG JEAN CUI ,  SAMANTHA ELIZABETH GREASLEY ,  ELIZABETH ANN LUNNEY ,  INDRAWAN JAMES MCALPINE ,  ASAKO NAGATA ,  SACHA NINKOVIC ,  KIYOYUKI OMOTO ,  SARAH ELIZABETH SKERRATT ,  ROBERT IAN STORER ,  JOSEPH SCOTT WARMUS

IPC: C07D401/14 ,  C07D413/14 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，其中取代基如本文所述，及其在药物中的用途，特别是作为TrkA拮抗剂。