公开(公告)号：US20150322043A1

公开(公告)日：2015-11-12

申请号：US14705272

申请日：2015-05-06

Applicant: PFIZER INC

Inventor： SHARANJEET KAUR BAGAL ,  JINGRONG JEAN CUI ,  SAMANTHA ELIZABETH GREASLEY ,  ELIZABETH ANN LUNNEY ,  INDRAWAN JAMES MCALPINE ,  ASAKO NAGATA ,  SACHA NINKOVIC ,  KIYOYUKI OMOTO ,  SARAH ELIZABETH SKERRATT ,  ROBERT IAN STORER ,  JOSEPH SCOTT WARMUS

IPC: C07D401/14 ,  C07D413/14 ,  C07D401/12

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，其中取代基如本文所述，及其在药物中的用途，特别是作为TrkA拮抗剂。