公开(公告)号：US20170050958A1

公开(公告)日：2017-02-23

申请号：US15306979

申请日：2015-04-17

Applicant: PFIZER INC.

Inventor： Aaron Craig BURNS ,  Michael Raymond COLLINS ,  Samantha Elizabeth GREASLEY ,  Robert Louis Hoffman ,  Peter Qinhua HUANG ,  Robert Steven Kania ,  Pei-Pei KUNG ,  Maria Angelica LINTON ,  Lakshmi Sourirajan NARASIMHAN ,  Paul Francis RICHARDSON ,  Daniel Tyler RICHTER ,  Graham SMITH

IPC: C07D417/14 ,  A61K45/06 ,  A61K31/501 ,  C07D401/14 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/444 ,  C07D277/46

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中A，L，D，R 1 -R 15，w，x，y和z在本文中定义。 在哺乳动物中可用于治疗异常细胞生长例如癌症的新型环烷基连接的二杂环衍生物。 本发明还涉及含有该化合物的药物组合物以及使用该化合物和组合物治疗哺乳动物异常细胞生长的方法。

公开(公告)号：US20180148441A1

公开(公告)日：2018-05-31

申请号：US15826027

申请日：2017-11-29

Applicant: PFIZER INC.

Inventor： Aaron Craig BURNS ,  Michael Raymond COLLINS ,  Samantha Elizabeth GREASLEY ,  Robert Louis Hoffman ,  Peter Qinhua HUANG ,  Robert Steven Kania ,  Pei-Pei KUNG ,  Maria Angelica LINTON ,  Lakshmi Sourirajan NARASIMHAN ,  Paul Francis RICHARDSON ,  Daniel Tyler RICHTER ,  Graham SMITH

IPC: C07D417/14 ,  C07D417/08 ,  C07D277/46 ,  A61K45/06 ,  A61K31/427 ,  A61K31/501 ,  A61K31/444 ,  A61K31/4439 ,  C07D401/14 ,  A61K31/506

CPC classification number: C07D417/14 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D277/46 ,  C07D401/14 ,  C07D417/08

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

公开(公告)号：US20160115178A1

公开(公告)日：2016-04-28

申请号：US14898582

申请日：2014-06-17

Applicant: PFIZER INC.

Inventor： Andrew James JENSEN ,  Suman LUTHRA ,  Paul Francis RICHARDSON

IPC: C07D498/18

CPC classification number: C07D498/18

Abstract: This invention relates to crystalline solvates of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to pharmaceutical compositions comprising such crystalline solvates, and to methods of using such solvates and compositions in the treatment of abnormal cell growth in mammals, especially humans.

Abstract translation: 本发明涉及（10R）-7-氨基-12-氟-2,10,16-三甲基-15-氧代-10,15,16,17-四氢-2H-8,4-（甲苯）的结晶溶剂化物， 吡唑并[4,3-h] [2,5,11]苯并二氮杂环十四碳烯-3-腈，可用于治疗哺乳动物中异常细胞生长，如癌症。 本发明还涉及包含这种结晶溶剂合物的药物组合物，以及使用这些溶剂合物和组合物治疗哺乳动物尤其是人类异常细胞生长的方法。