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    ANTIBODIES SPECIFIC FOR DKK-1 AND THEIR USES
    1.
    发明申请
    ANTIBODIES SPECIFIC FOR DKK-1 AND THEIR USES 失效
    DKK-1特异性抗体及其用途

    公开(公告)号：US20130071921A1

    公开(公告)日：2013-03-21

    申请号：US13680569

    申请日：2012-11-19

    申请人： PFIZER INC. ,  RINAT NEUROSCIENCE CORP.

    发明人： Vishwas Madhav PARALKAR ,  Donna Marie STONE ,  Mei LI ,  Jaume PONS

    IPC分类号： C07K16/28 ,  C12N15/85 ,  C12N15/70

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/70 ,  C12N15/85

    摘要： The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+ cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders, such as bone disorders, which result in a loss of bone. Methods of treating or preventing a loss of bone mass, methods of inducing increased bone mass, and methods of inducing Wnt activity are also provided.

    摘要翻译： 本发明提供了与Dkk-1结合的抗体及其片段，特别是结合Dkk-1的人源化抗体及其片段，更具体地，涉及与Dkk-1结合的完全人源化抗体和免疫功能片段 。 还提供了与抗小鼠Dkk-1单克隆抗体与Dkk-1 +细胞的结合竞争的抗体及其片段。 还提供了编码抗-Dkk-1抗体或其片段的核酸，以及掺入这些核酸用于重组表达抗-Dkk-1抗体及其片段的表达载体和宿主细胞。 还提供了制备本发明的抗体及其片段的方法。 还提供骨合成代谢剂。 还提供了包含本发明的抗体或其片段的药物组合物。 还提供了治疗导致骨丢失的疾病，病症和障碍（例如骨骼疾病）的方法。 还提供了治疗或预防骨量丧失的方法，诱导骨量增加的方法和诱导Wnt活性的方法。