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公开(公告)号:US20030130170A1
公开(公告)日:2003-07-10
申请号:US10298349
申请日:2002-11-18
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K038/16 , A61K038/13
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20030166507A1
公开(公告)日:2003-09-04
申请号:US10300031
申请日:2002-11-20
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David Yang
IPC分类号: A61K038/16 , A61N005/00
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20030130341A1
公开(公告)日:2003-07-10
申请号:US10298375
申请日:2002-11-18
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K031/337 , C07D35/14
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20030113335A1
公开(公告)日:2003-06-19
申请号:US10243046
申请日:2002-09-12
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K039/395 , C12N009/00 , C07K016/46
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20030147807A1
公开(公告)日:2003-08-07
申请号:US10310331
申请日:2002-12-05
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K051/00 , A61K031/7048 , A61K031/337 , A61K031/4745 , A61K031/427 , A61K031/555
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20030134793A1
公开(公告)日:2003-07-17
申请号:US10282570
申请日:2002-10-28
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K038/16 , A61K031/337
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or -lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
摘要翻译: 公开了通过将紫杉醇或多西他赛与水溶性聚合物如聚谷氨酸,聚天冬氨酸或 - 赖氨酸缀合而形成的紫杉醇和多西紫杉醇的水溶性组合物。 还公开了使用组合物治疗肿瘤,自身免疫疾病如类风湿性关节炎的方法。 其他实施方案包括用于预防再狭窄的可植入支架的涂层。
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公开(公告)号:US20030130178A1
公开(公告)日:2003-07-10
申请号:US10298327
申请日:2002-11-18
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K038/16 , A61K031/7048 , A61K031/704 , A61K031/4745 , A61K031/56
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
摘要翻译: 公开了通过将紫杉醇或多西他赛与水溶性聚合物如聚谷氨酸,聚天冬氨酸或聚赖氨酸缀合而形成的紫杉醇和多西他赛的水溶性组合物。 还公开了使用组合物治疗肿瘤,自身免疫疾病如类风湿性关节炎的方法。 其他实施方案包括用于预防再狭窄的可植入支架的涂层。
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公开(公告)号:US20030124055A1
公开(公告)日:2003-07-03
申请号:US10310511
申请日:2002-12-05
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K051/00 , A61K031/7048 , A61K031/4745 , A61K031/427 , A61K031/337
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20030073617A1
公开(公告)日:2003-04-17
申请号:US10282490
申请日:2002-10-28
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David J. Yang
IPC分类号: A61K038/16 , A61K031/7048 , A61K031/704 , A61K031/4745 , A61K031/337 , A61K038/13
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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公开(公告)号:US20040198638A1
公开(公告)日:2004-10-07
申请号:US10826302
申请日:2004-04-19
申请人: PG-TXL Company, L.P.
发明人: Chun Li , Sidney Wallace , Dong-Fang Yu , David Yang
IPC分类号: A61K038/00 , A61K031/337
CPC分类号: A61K41/0038 , A61K31/337 , A61K31/4375 , A61K38/13 , A61K47/547 , A61K47/59 , A61K47/60 , A61K47/645 , A61K51/0497 , A61K51/065 , A61K2121/00 , A61K2123/00 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08G73/1092
摘要: Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.
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