公开(公告)号：US20200348303A1

公开(公告)日：2020-11-05

申请号：US16642910

申请日：2018-08-30

申请人： PHASE DIAGNOSTICS, INC.

发明人： Yin To CHIU ,  Garrett Lee MOSLEY ,  Brian Sangwoo LEE

IPC分类号： G01N33/571 ,  G01N1/34 ,  G01N33/543 ,  G01N1/40

摘要： This invention relates to a method and device for improving the accuracy and performance of detecting or diagnosing sexually transmitted infections (STIs) or STI-causing pathogens. In one embodiment, the present method and device are related to removing one or more interfering molecules such as urea from urine sample, where these interfering molecules alter the performance of Lateral-Flow Immunoassay (LFA). In one embodiment, an aqueous two-phase system (ATPS) embedded entirely within a porous material allows spontaneous phase separation and the target STI-causing pathogens is concentrated in one of the separated phases. In one embodiment, a detection module such as the Lateral-Flow Immunoassay (LFA) is used in connection with other modules so as to detect or diagnose the sexually transmitted infections or the pathogens associated with STIs with an improved performance.

公开(公告)号：US20200318153A1

公开(公告)日：2020-10-08

申请号：US16642918

申请日：2018-08-30

申请人： PHASE DIAGNOSTICS, INC.

发明人： Yin To CHIU ,  Garrett Lee MOSLEY ,  Brian Sangwoo LEE

IPC分类号： C12Q1/06 ,  G01N1/34

摘要： This invention relates to a method and device to improve the detection accuracy and performance for diagnosing dental disorders or diseases by improving the sensitivity of the Lateral-Flow Immunoassay (LFA). The present method and device are related to removing the protein interference (impurities) from sample and using aqueous two-phase system (ATPS) embedded entirely within a porous material, allowing spontaneous phase separation and concentration, for detection using the Lateral-Flow Immunoassay (LFA). The present invention also provides a platform technology for screening different types of specimens with increased sensitivity, and screening antibodies for optimal detection in various types of samples.

公开(公告)号：US20240173648A1

公开(公告)日：2024-05-30

申请号：US18436054

申请日：2024-02-08

申请人： PHASE DIAGNOSTICS, INC.

发明人： Yin To CHIU ,  Brian Sangwoo LEE ,  Garrett Lee MOSLEY ,  Beatrice S. LIM

IPC分类号： B01D17/02 ,  B01D11/04 ,  B01D15/00 ,  B01D17/12 ,  B01D19/00 ,  B01J20/32 ,  C07K1/14 ,  C07K1/36 ,  G01N1/40

CPC分类号： B01D17/0214 ,  B01D11/0492 ,  B01D15/00 ,  B01D17/02 ,  B01D17/0202 ,  B01D17/12 ,  B01D19/0057 ,  B01J20/3208 ,  B01J20/3274 ,  B01J20/3287 ,  B01J20/3289 ,  C07K1/145 ,  C07K1/36 ,  G01N1/405 ,  G01N2001/4061

摘要： The present invention relates to a method and/or device for improving the separation behaviors and performance of aqueous two-phase system (ATPS) for the isolation and/or concentration of one or more target analytes from a sample. In one embodiment, the present method and device comprise ATPS components within a porous material and one or more phase separation behavior modifying agents that improve the separation behavior and performance characteristics of ATPS, including but not limited to the increasing the stability or reducing fluctuations of ATPS thought the adjustment of total volume of a sample solution that undergoes phase separation, volume ratio of the two phases of the ATPS, fluid flow rates, and concentrations of ATPS components.