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公开(公告)号：US20150080312A1
公开(公告)日：2015-03-19
申请号：US14399321
申请日：2013-05-06
发明人： Prabhu Dutt Mishra , Sreekumar Sankaranarayanan Eyyammadichiyl , Saji David George , Shailendra Sonawane , Narayan Subhash Chakor , Abhijit Roychowdhury , Rajiv Sharma
IPC分类号： C07K7/64
摘要： This invention relates to an isolated, compound of Formula (1) or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of Formula (1) or the derivatives thereof. The present invention further relates to processes for the production of the compound of Formula (1) by fermentation of the fungal strain of Actinomycetes (PM0895172/MTCC 684), pharmaceutical compositions comprising the compound of Formula (1) as the active ingredient; and use of the compounds or composition containing them in the treatment of cancer.
摘要翻译： 本发明涉及分离的式（1）化合物或其衍生物或药学上可接受的盐。 本发明还包括式（1）化合物或其衍生物的所有异构体和互变异构形式。 本发明还涉及通过发酵放线菌真菌菌株（PM0895172 / MTCC684）生产式（1）化合物的方法，包含式（1）化合物作为活性成分的药物组合物; 以及使用含有它们的化合物或组合物治疗癌症。
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公开(公告)号：US09475842B2
公开(公告)日：2016-10-25
申请号：US14399321
申请日：2013-05-06
发明人： Prabhu Dutt Mishra , Sreekumar Sankaranarayanan Eyyammadichiyl , Saji David George , Shailendra Sonawane , Narayan Subhash Chakor , Abhijit Roychowdhury , Rajiv Sharma
摘要： This invention relates to an isolated compound of Formula (1) or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of Formula (1) or the derivatives thereof. The present invention further relates to processes for the production of the compound of Formula (1) by fermentation of the fungal strain of Actinomycetes (PM0895172/MTCC 684), pharmaceutical compositions comprising the compound of Formula (1) as the active ingredient; and use of the compounds or composition containing them in the treatment of cancer.
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公开(公告)号：US10105373B2
公开(公告)日：2018-10-23
申请号：US15318973
申请日：2015-06-24
摘要： The present invention discloses fused triterpene compounds, represented by the compounds of Formula I (as described herein), processes for their preparation, pharmaceutical compositions comprising the said compounds, their use as retinoid-related orphan receptors gamma (RORγ) modulators and/or interleukin-17 (IL-17) inhibitors and methods for their use in the treatment of a disease or a disorder mediated by RORγ and/or IL-17.
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