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12 条记录 (耗时 0.026 秒)

    HEXADEPSIPEPTIDE ANALOGUES AS ANTICANCER COMPOUNDS
    3.
    发明申请
    HEXADEPSIPEPTIDE ANALOGUES AS ANTICANCER COMPOUNDS 有权
    十六烷基哌啶类似物作为抗体化合物

    公开(公告)号：US20150080312A1

    公开(公告)日：2015-03-19

    申请号：US14399321

    申请日：2013-05-06

    申请人： PIRAMAL ENTERPRISES LIMITED

    发明人： Prabhu Dutt Mishra ,  Sreekumar Sankaranarayanan Eyyammadichiyl ,  Saji David George ,  Shailendra Sonawane ,  Narayan Subhash Chakor ,  Abhijit Roychowdhury ,  Rajiv Sharma

    IPC分类号： C07K7/64

    CPC分类号： A61K38/15 ,  A61K38/00 ,  C07K7/64 ,  C07K11/02

    摘要： This invention relates to an isolated, compound of Formula (1) or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of Formula (1) or the derivatives thereof. The present invention further relates to processes for the production of the compound of Formula (1) by fermentation of the fungal strain of Actinomycetes (PM0895172/MTCC 684), pharmaceutical compositions comprising the compound of Formula (1) as the active ingredient; and use of the compounds or composition containing them in the treatment of cancer.

    摘要翻译： 本发明涉及分离的式（1）化合物或其衍生物或药学上可接受的盐。 本发明还包括式（1）化合物或其衍生物的所有异构体和互变异构形式。 本发明还涉及通过发酵放线菌真菌菌株（PM0895172 / MTCC684）生产式（1）化合物的方法，包含式（1）化合物作为活性成分的药物组合物; 以及使用含有它们的化合物或组合物治疗癌症。

    PHENYL ALKANOIC ACID DERIVATIVES AS GPR AGONISTS
    10.
    发明申请
    PHENYL ALKANOIC ACID DERIVATIVES AS GPR AGONISTS 审中-公开
    苯丙酸衍生物作为GPR激素

    公开(公告)号：US20150072969A1

    公开(公告)日：2015-03-12

    申请号：US14381696

    申请日：2013-02-27

    申请人： PIRAMAL ENTERPRISES LIMITED

    发明人： Sanjay Kumar ,  Rajiv Sharma ,  Vishal Ashok Mahajan ,  Sangameshwar Prabhakar Sawargave

    IPC分类号： C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D205/04 ,  C07D305/06 ,  C07D407/12

    CPC分类号： C07D413/12 ,  C07D205/04 ,  C07D305/06 ,  C07D307/08 ,  C07D335/02 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

    摘要： The present invention relates to phenyl alkanoic acid derivatives (the compounds of Formula (I)); and their isotopic forms, stereoisomeric and tautomeric forms and mixtures thereof in all ratios, or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, polymorphs, N-oxides, S-oxides or carboxylic acid isosteres thereof. The invention also relates to processes for the preparation of compounds of Formula (I) and pharmaceutical compositions comprising one or more of the compounds of Formula (I). The said compounds and the pharmaceutical composition function as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists, and are useful in the treatment of diseases or conditions mediated by GPR40. The present invention further relates to a method of treatment of diseases or conditions mediated by GPR40 comprising administering to a subject in need thereof a therapeutically effective amount of the compounds of Formula (I).

    摘要翻译： 本发明涉及苯基链烷酸衍生物（式（I）的化合物）; 和它们的同位素形式，立体异构体和互变异构形式及其各种比例的混合物，或其药学上可接受的盐，药学上可接受的溶剂化物，前药，多晶型物，N-氧化物，S-氧化物或羧酸等体积。 本发明还涉及制备式（I）化合物和包含一种或多种式（I）化合物的药物组合物的方法。 所述化合物和药物组合物用作GPR（G-蛋白偶联受体）激动剂，特别是作为GPR40激动剂，并且可用于治疗由GPR40介导的疾病或病症。 本发明还涉及一种治疗由GPR40介导的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的式（I）化合物。