公开(公告)号：US20230332081A1

公开(公告)日：2023-10-19

申请号：US18042376

申请日：2021-08-13

Applicant: POLITECNICO DI MILANO ,  OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Gianfranco Beniamino FIORE ,  Monica SONCINI ,  Marco PIOLA ,  Lorenzo Pietro COPPADORO ,  Chiara FOGLIENI ,  Maria LOMBARDI

IPC: C12M3/00

CPC classification number: C12M23/42 ,  C12M23/48

Abstract: A cartridge is adapted to house at least one biological sample therein, where the cartridge contains at least two overlapping layers, and the layers include at least one layer of highly hydrophobic, inert, and biocompatible material, with contact angle Θc≥90°, hydrophobic layer, and optionally, at least one layer of double-sided adhesive material, where in the absence of the at least one layer of double-sided adhesive material, the overlapping layers are connected together by chemical and/or physical bonding, where each of the overlapping layers has at least one inner hole that is pervious when the layers overlap one another, and the at least one inner hole is closed by the at least one biological sample, where loaded in the cartridge.

公开(公告)号：US20220273414A1

公开(公告)日：2022-09-01

申请号：US17629051

申请日：2020-07-17

Applicant: POLITECNICO DI MILANO ,  CENTRO CARDIOLOGICO MONZINO S.P.A. ,  UNIVERSITA' DEGLI STUDI DI MILANO

Inventor： Gianfranco Beniamino FIORE ,  Monica SONCINI ,  Marco PIOLA ,  Maurizio PESCE ,  Marco AGRIFOGLIO

IPC: A61F2/06 ,  A01N1/02

Abstract: A conditioning device for conditioning an exposed stretch of a blood vessel has an envelope and at least one conveying channel extending entirely within the envelope. The envelope has a first layer having a first surface facing the exposed stretch, and a second layer having a second surface, opposite to the first surface. The at least one conveying channel has at least one first aperture leading out of the envelope, so that the at least one conveying channel is suppliable with working fluid through the at least one first aperture. The first layer is permeable to at least one component of the working fluid, so that, when the working fluid is in the at least one conveying channel, the at least one component, permeating the first layer, diffuses until reaching the first surface to apply a conditioning action on the exposed stretch of the blood vessel.