公开(公告)号：US20250054639A1

公开(公告)日：2025-02-13

申请号：US18720084

申请日：2022-12-12

Applicant: CENTRO CARDIOLOGICO MONZINO S.p.A.

Inventor： Simone DI GREGORIO ,  Gianluca PONTONE ,  Alfio QUARTERONI ,  Christian VERGARA

IPC: G16H50/50

Abstract: A computer-implemented method for the simulation of myocardial blood flow under stress conditions comprises a step of generating a simulated multi-physics model of a myocardial perfusion, wherein the step of generating further comprises: a step of generating a simulated model of the epicardial vessels based on a three-dimensional fluid-dynamics description; a step of generating a simulated model of the intramural vessels based on a multi-compartment porous medium; a step of coupling the simulated model of the epicardial vessels and the simulated model of the intramural vessels; a step of automatic calibration of physical parameters of the simulated multi-physics model of a myocardial perfusion under stress conditions, wherein the calibrated physical parameters are permeability tensors, conductances between the epicardial coronary arteries and the intramural vessels, and inter-compartment conductances between the compartments.

公开(公告)号：US20240329063A1

公开(公告)日：2024-10-03

申请号：US18579109

申请日：2022-07-14

Applicant: Centro Cardiologico Monzino S.P.A. ,  Universita' Degli Studi di Milano

Inventor： Marina Camera ,  Marta Brambilla ,  Paola Canzano

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N2333/7454 ,  G01N2440/14

Abstract: Disclosed is a method for evaluating residual platelet thrombotic potential in patients undergoing antiplatelet treatment, which comprises determination in a patient's blood sample of vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) status and platelet tissue factor (TF) expression.

公开(公告)号：US20220273414A1

公开(公告)日：2022-09-01

申请号：US17629051

申请日：2020-07-17

Applicant: POLITECNICO DI MILANO ,  CENTRO CARDIOLOGICO MONZINO S.P.A. ,  UNIVERSITA' DEGLI STUDI DI MILANO

Inventor： Gianfranco Beniamino FIORE ,  Monica SONCINI ,  Marco PIOLA ,  Maurizio PESCE ,  Marco AGRIFOGLIO

IPC: A61F2/06 ,  A01N1/02

Abstract: A conditioning device for conditioning an exposed stretch of a blood vessel has an envelope and at least one conveying channel extending entirely within the envelope. The envelope has a first layer having a first surface facing the exposed stretch, and a second layer having a second surface, opposite to the first surface. The at least one conveying channel has at least one first aperture leading out of the envelope, so that the at least one conveying channel is suppliable with working fluid through the at least one first aperture. The first layer is permeable to at least one component of the working fluid, so that, when the working fluid is in the at least one conveying channel, the at least one component, permeating the first layer, diffuses until reaching the first surface to apply a conditioning action on the exposed stretch of the blood vessel.

公开(公告)号：US20150094348A1

公开(公告)日：2015-04-02

申请号：US14556007

申请日：2014-11-28

Applicant: Centro Cardiologico Monzino S.p.A.

Inventor： Mariapia Abbracchio ,  Ivano Eberini ,  Chiara Parravicini ,  Claudia Martini ,  Maria Letizia Trincavelli ,  Simona Daniele

IPC: A61K31/4196

CPC classification number: A61K31/4196 ,  A61K31/4192 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/519

Abstract: Disclosed are compounds able to modulate the activity of the GPR17 receptor in a highly specific way, which are useful in the treatment and diagnosis of diseases or dysfunctions involving the activation of said receptor. In particular, the compounds according to the invention can be used for neuroprotective and/or reparatory purposes, in cerebral, cardiac and renal ischaemia, in cerebral trauma, in chronic neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), and in demyelinating diseases such as multiple sclerosis.

Abstract translation: 公开了能够以高度特异性的方式调节GPR17受体的活性的化合物，其可用于治疗和诊断涉及所述受体活化的疾病或功能障碍。 特别地，根据本发明的化合物可用于脑，心脏和肾脏局部缺血，脑创伤，慢性神经变性疾病如肌萎缩性侧索硬化（ALS）中的神经保护和/或修复目的，以及脱髓鞘疾病 作为多发性硬化。