公开(公告)号：US20190167761A1

公开(公告)日：2019-06-06

申请号：US16197491

申请日：2018-11-21

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sang Ki PARK ,  Nhung TRUONG ,  Sung Jin PARK ,  Yeong Jun SUH ,  Cana PARK

IPC: A61K38/17 ,  A61P25/24 ,  A61P25/22 ,  G01N33/50 ,  A61K35/30 ,  C12Q1/02

Abstract: Provided herein are a pharmaceutical composition for preventing or treating a stress-related disease, which includes the DISC1 protein or a gene encoding the DISC protein, and a method of screening a material for preventing or treating the stress-related disease. As a result of studying the association between DISC1 and psychological stress, the inventors of the present disclosure verified the function of DISC1 in downregulating ER-mitochondria Ca2+ transfer induced by stress hormone-mediated oxidative stress by competitively inhibiting the binding of IP3 to inositol 1,4,5-trisphosphate (IP3) receptor type1 (IP3R1) by binding to the IP3R1 at the MAM, and an acting site of DISC1, and this provides a model of intracellular calcium response to physiological stress, and DISC1, a stress modulating substance, and the model may be usefully used in related fields for the prevention and treatment of stress-related diseases.