公开(公告)号：US20190167761A1

公开(公告)日：2019-06-06

申请号：US16197491

申请日：2018-11-21

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sang Ki PARK ,  Nhung TRUONG ,  Sung Jin PARK ,  Yeong Jun SUH ,  Cana PARK

IPC: A61K38/17 ,  A61P25/24 ,  A61P25/22 ,  G01N33/50 ,  A61K35/30 ,  C12Q1/02

Abstract: Provided herein are a pharmaceutical composition for preventing or treating a stress-related disease, which includes the DISC1 protein or a gene encoding the DISC protein, and a method of screening a material for preventing or treating the stress-related disease. As a result of studying the association between DISC1 and psychological stress, the inventors of the present disclosure verified the function of DISC1 in downregulating ER-mitochondria Ca2+ transfer induced by stress hormone-mediated oxidative stress by competitively inhibiting the binding of IP3 to inositol 1,4,5-trisphosphate (IP3) receptor type1 (IP3R1) by binding to the IP3R1 at the MAM, and an acting site of DISC1, and this provides a model of intracellular calcium response to physiological stress, and DISC1, a stress modulating substance, and the model may be usefully used in related fields for the prevention and treatment of stress-related diseases.

公开(公告)号：US20210318325A1

公开(公告)日：2021-10-14

申请号：US16316087

申请日：2017-11-22

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sang Ki PARK ,  Yeong Jun SUH ,  Seung Hyun KIM

IPC: G01N33/58 ,  G01N21/64 ,  G01N33/84 ,  G01N33/68

Abstract: The present disclosure relates to a Mitochondria-Associated endoplasmic reticulum Membrane (MAM)-specific fluorescence calcium sensor and the use thereof. The present disclosure can surmount the limitations of a conventional technique in that verification of calcium migration through MAM requires separate measurements of calcium ion concentrations within ER and mitochondria and situational explanations of the phenomena, and can directly measure concentrations in the paths through which calcium ions move to exclude influences on calcium ion changes through numerous different calcium ion channels existing in mitochondria, thereby providing a convenient and accurate MAM-specific calcium ion sensor.

公开(公告)号：US20230204598A1

公开(公告)日：2023-06-29

申请号：US16316076

申请日：2017-11-22

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sang Ki PARK ,  Yeong Jun SUH ,  Bon Seong GOO

IPC: G01N33/68 ,  G01N33/58 ,  G01N21/64

CPC classification number: G01N33/6872 ,  G01N33/582 ,  G01N21/6428

Abstract: The present discloure relates to a Mitochondria-Associated endoplasmic reticulum Membrane (MAM)-specific targeting bimolecular fluorescence complement system and the use thereof. The system of the present discloure can be utilized under in vivo conditions in contrast to conventional electron microscopy and MAM centrifugation techniques used in order to verify MAM specificity, is far more convenient and accurate than a method of indirectly verifying the specificity of MAM by using respective ER and mitochondria fluorescence markers, and can apply all preexisting genetic techniques for the selection of expression tissues or time, thus gaining the advantage of having high availability.