公开(公告)号：US20230375549A1

公开(公告)日：2023-11-23

申请号：US17998334

申请日：2021-05-12

申请人： PRELUDE CORPORATION

发明人： Axel Emanuel Stenmark Tullberg ,  Erik Carl Viktor Holmberg ,  Per Oswald Karlsson ,  Troy M. Bremer

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  G01N2333/70532 ,  G01N2800/52

摘要： Provided are embodiments for treating breast cancer comprising obtaining a tissue sample of a tumour from a breast cancer patient, determining an expression level of PD-1 in the sample, determining that the expression level is below a threshold level, providing intensified treatment to the subject. The intensified treatment can be intensified radiotherapy treatment.

公开(公告)号：US20220341936A1

公开(公告)日：2022-10-27

申请号：US17657537

申请日：2022-03-31

申请人： PRELUDE CORPORATION

发明人： Axel Emanuel Stenmark Tullberg ,  Erik Carl Viktor Holmberg ,  Per Oswald Karlsson ,  Troy M. Bremer

IPC分类号： G01N33/574 ,  C07K16/28 ,  C12Q1/6886 ,  A61N5/10

摘要： Methods for treating and/or prognosing breast cancer and breast cancer recurrence are provided. The method includes obtaining a tissue sample of a tumor from a breast cancer patient, determining an expression level of one or more markers (for example PD-1 and/or PD-L1) in the sample, and providing intensified treatment to the subject based on the level of (for example) PD-1 and/or PD-L1. The intensified treatment can be intensified radiotherapy treatment.

公开(公告)号：US20230392209A1

公开(公告)日：2023-12-07

申请号：US18033054

申请日：2021-10-20

申请人： Prelude Corporation ,  University of Bergen ,  TECKNET AB ,  Per-Olof Malmström ,  Lars Mårten Fernö

发明人： Carina Strell ,  Carl Arne Östman ,  Axel Emanuel Stenmark Tullberg ,  Erik Carl Viktor Holmberg ,  Per Oswald Karlsson ,  Per-Olof Malmström ,  Lars Mårten Fernö ,  Lars Andreas Akslen ,  Troy M. Bremer ,  Reidunn Jetne Edelmann

IPC分类号： C12Q1/6886 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/57415 ,  G01N2333/49 ,  C12Q2600/158 ,  G01N2800/52 ,  C12Q2600/106

摘要： Provided herein are various methods for treating a subject for local and/or regional recurrence of invasive breast cancer or a subject with invasive breast cancer, identifying a subject who will not be adequately responsive to radiation therapy, recommending a treatment to a subject, preventing an invasive breast cancer recurrence in a subject, preventing a local and/or regional recurrence of an invasive breast cancer in a subject, or modifying a treatment for a subject based on PDGFRb levels. In some embodiments, the methods are based on PDGFRb levels.