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公开(公告)号：US20150209783A1
公开(公告)日：2015-07-30
申请号：US14424195
申请日：2013-09-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Geraldine A. Hamilton , Daniel Levner , Christopher Hinojosa , Daniel Patterson
CPC classification number: B01L3/502723 , B01D17/085 , B01D19/0031 , B01D63/088 , B01D71/36 , B01D2325/38 , B01L3/502715 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M23/36
Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.
Abstract translation: 微流体系统包括连接到气泡捕获装置的微流体装置，由此流到微流体装置的流体通过气泡捕获装置以在进入微流体装置之前去除气泡。 气泡阱可以包括由疏水性多孔膜隔开的分离室和排气室，并且进入分离室的流体中的气泡在流体保留在分离室中时通过疏水性多孔膜进入排气室。 可以通过将第一主体部分接合到疏水性多孔膜的第一侧并将第二主体部分结合到疏水性多孔膜的第二侧来形成气泡捕获器。 排气室可以连接到细长的排气通道，其限制流体通过疏水多孔膜的蒸发损失。
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公开(公告)号：US09962698B2
公开(公告)日：2018-05-08
申请号：US14424195
申请日：2013-09-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Geraldine A. Hamilton , Daniel Levner , Christopher Hinojosa , Daniel Patterson
CPC classification number: B01L3/502723 , B01D17/085 , B01D19/0031 , B01D63/088 , B01D71/36 , B01D2325/38 , B01L3/502715 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M23/36
Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.
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