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公开(公告)号：US11773359B2
公开(公告)日：2023-10-03
申请号：US17146264
申请日：2021-01-11
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Anthony Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC: C12M3/06 , C12M1/34 , G01N33/50 , B01L3/00 , B01L9/00 , C12M3/00 , C12M1/00 , C12M1/42 , A01N1/02
CPC classification number: C12M23/16 , A01N1/02 , B01L3/502715 , B01L9/52 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , C12M41/00 , G01N33/5082 , G01N33/5088 , A01N1/021 , A01N1/0247 , A01N1/0273 , B01L3/5027 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0867 , B01L2300/0877 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M41/12 , C12M41/46 , G01N33/5005
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
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公开(公告)号：US20210003561A1
公开(公告)日：2021-01-07
申请号：US17019102
申请日：2020-09-11
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa , Carolina Lucchesi
Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
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公开(公告)号：US20190032021A1
公开(公告)日：2019-01-31
申请号：US16125433
申请日：2018-09-07
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Kevin Kit Parker , Geraldine A. Hamilton , Anthony Bahinski
Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
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公开(公告)号：US09962698B2
公开(公告)日：2018-05-08
申请号：US14424195
申请日：2013-09-04
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Geraldine A. Hamilton , Daniel Levner , Christopher Hinojosa , Daniel Patterson
CPC classification number: B01L3/502723 , B01D17/085 , B01D19/0031 , B01D63/088 , B01D71/36 , B01D2325/38 , B01L3/502715 , B01L2200/0684 , B01L2300/06 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , C12M23/16 , C12M23/24 , C12M23/36
Abstract: A microfluidic system includes a microfluidic device connected to a bubble trap device whereby fluid flowing to the microfluidic device passes through the bubble trap device to remove gas bubbles prior to entering the microfluidic device. The bubble trap can include a separation chamber and an exhaust chamber separated by a hydrophobic porous membrane and gas bubbles in the fluid entering the separation chamber pass through the hydrophobic porous membrane into the exhaust chamber while the fluid remains in the separation chamber. The bubble trap can be formed by bonding a first body portion to a first side of the hydrophobic porous membrane and bonding a second body portion to a second side of the hydrophobic porous membrane. The exhaust chamber can be connected to an elongated exhaust channel that limits the evaporation losses of the fluid through the hydrophobic porous membrane.
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公开(公告)号：US20230348831A1
公开(公告)日：2023-11-02
申请号：US18346165
申请日：2023-06-30
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Anthony M. Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC: C12M3/06 , A01N1/02 , C12M1/34 , G01N33/50 , B01L3/00 , B01L9/00 , C12M3/00 , C12M1/00 , C12M1/42
CPC classification number: C12M23/16 , A01N1/02 , C12M41/00 , G01N33/5082 , B01L3/502715 , B01L9/52 , C12M21/08 , C12M23/42 , C12M29/10 , C12M35/04 , C12M35/08 , G01N33/5088 , A01N1/0247 , G01N33/5005 , A01N1/0273 , A01N1/021 , B01L3/5027 , C12M41/46 , C12M41/12 , B01L2300/0877 , B01L2300/0867 , B01L2200/0684 , B01L2200/0689 , B01L2200/146 , B01L2200/147 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/123 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
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Patent Agency Ranking
公开(公告)号：US20170327781A1
公开(公告)日：2017-11-16
申请号：US15601430
申请日：2017-05-22
Applicant: President and Fellows of Harvard College
Inventor： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer
CPC classification number: C12M23/16 , C12M21/08 , C12M23/26 , C12M25/02 , C12M35/04 , C12M41/00 , C12M41/46
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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7.发明申请公开(公告)号：US20160313306A1
公开(公告)日：2016-10-27
申请号：US15105962
申请日：2014-12-19
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Donald E. Ingber , Kambez Hajipouran Benam , Remi Villenave , Geraldine A. Hamilton , Bryan Hassell , Christopher D. Hinojosa
CPC classification number: G01N33/5044 , B01L3/5027 , C12M21/08 , C12M23/16 , C12M25/02 , C12M35/04 , C12M41/46 , G01N2800/122
Abstract: Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel. The height of the mesochannel is substantially greater than the height of the microchannel. A gaseous fluid can be applied through the mesochannel while a liquid fluid flowing through the microchannel. The systems and methods described herein can be used for various applications, including, e.g., growth and differentiation of primary cells such as human lung cells, as well as any other cells requiring low shear and/also stratified structures, or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents and/or vaccines). The systems and methods can also permit co-culture with one or more different cell types.
Abstract translation: 本文涉及用于生产和使用具有由一个或多个隔膜分隔的中心通道的主体的系统和方法。 膜被配置为将中心通道分成至少一个中间通道和至少一个微通道。 中间通道的高度明显大于微通道的高度。 气体流体可以通过中间通道施加，同时液体流体流过微通道。 本文描述的系统和方法可用于各种应用，包括例如原代细胞如人肺细胞的生长和分化以及需要低剪切和/或分层结构的任何其它细胞，或微环境的模拟 活组织和/或器官（用于模拟生理学或疾病状态，和/或鉴定治疗剂和/或疫苗）。 系统和方法还可以允许与一种或多种不同细胞类型的共培养。
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公开(公告)号：US12187997B2
公开(公告)日：2025-01-07
申请号：US18346165
申请日：2023-06-30
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Anthony M. Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC: C12M3/06 , A01N1/02 , B01L3/00 , B01L9/00 , C12M1/00 , C12M1/34 , C12M1/42 , C12M3/00 , G01N33/50
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
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公开(公告)号：US20240425788A1
公开(公告)日：2024-12-26
申请号：US18755633
申请日：2024-06-26
Applicant: President and Fellows of Harvard College
Inventor： Donald E. Ingber , Anthony M. Bahinski , Robert Cunningham , Josue A. Goss , Geraldine A. Hamilton , Christopher David Hinojosa , Daniel Levner , Kevin Kit Parker
IPC: C12M3/06 , A01N1/02 , B01L3/00 , B01L9/00 , C12M1/00 , C12M1/34 , C12M1/42 , C12M3/00 , G01N33/50
Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
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公开(公告)号：US12173263B2
公开(公告)日：2024-12-24
申请号：US15105388
申请日：2014-12-19
Applicant: President and Fellows of Harvard College , Jose Fernandez-Alcon , Norman Wen , Richard Novak
Inventor： Jose Fernandez-Alcon , Norman Wen , Richard Novak , Donald E. Ingber , Geraldine A. Hamilton , Christopher Hinojosa , Karel Domansky , Daniel Levner , Guy Thompson, II , Kambez Hajipouran Benam , Remi Villenave , Thomas Umundum , Alfred Paris , Georg Bauer
IPC: C12M3/06 , B01D61/18 , B01D63/08 , B01D67/00 , B01L3/00 , C12M1/00 , C12M1/12 , C12M1/34 , C12M1/42 , C12M3/00
Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.
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