公开(公告)号：US20220372423A1

公开(公告)日：2022-11-24

申请号：US17871054

申请日：2022-07-22

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. Ingber ,  Daniel LEVNER ,  Guy THOMPSON, III ,  Jose FERNANDEZ-ALCON ,  Christopher David HINOJOSA

IPC: C12M1/00 ,  C12M3/06 ,  B01L3/00 ,  C12M3/00 ,  C12M1/12 ,  C12M1/36

Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.

公开(公告)号：US20160145555A1

公开(公告)日：2016-05-26

申请号：US14904640

申请日：2014-06-11

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. INGBER ,  Daniel LEVNER ,  Guy THOMPSON, III ,  Jose FERNANDEZ-ALCON ,  Christopher David HINOJOSA

IPC: C12M1/00 ,  C12M1/36 ,  C12M1/12 ,  C12M3/00 ,  C12M3/06

Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.

Abstract translation: 系统和方法通过在设备之间传送离散体积的流体来互连细胞培养装置和/或流体装置。 液体处理系统从至少一个源装置收集一定体积的流体并将流体沉积到至少一个目的地装置中。 在一些实施例中，液体处理机器人以自动方式致动流体收集装置的移动和操作，以在至少一个源装置和至少一个目的地装置之间传送流体。 在一些情况下，至少一个源装置和至少一个目的装置是细胞培养装置。 所述至少一个源装置和所述至少一个目的地装置可以是微流体或非微流体装置。 在一些情况下，细胞培养装置可以是微流体细胞培养装置。 在另外的情况下，微流体细胞培养装置可以包括器官芯片。