公开(公告)号：US20240110159A1

公开(公告)日：2024-04-04

申请号：US18535216

申请日：2023-12-11

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Donald E. INGBER ,  Hyun Jung Kim

IPC分类号： C12N5/071 ,  C12M1/00 ,  C12M1/06 ,  C12M1/12 ,  C12M1/24 ,  C12M1/34 ,  C12M1/42 ,  C12M3/00 ,  C12N1/14 ,  C12N1/20 ,  C12N5/074

CPC分类号： C12N5/0697 ,  C12M21/08 ,  C12M23/08 ,  C12M23/20 ,  C12M23/26 ,  C12M23/34 ,  C12M23/38 ,  C12M25/02 ,  C12M27/02 ,  C12M29/04 ,  C12M29/06 ,  C12M35/04 ,  C12M35/08 ,  C12M41/12 ,  C12M41/26 ,  C12M41/40 ,  C12M41/44 ,  C12N1/14 ,  C12N1/20 ,  C12N5/0679 ,  C12N5/068 ,  C12N5/0696

摘要： The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.

公开(公告)号：US20230242918A1

公开(公告)日：2023-08-03

申请号：US17926748

申请日：2021-05-21

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Longlong SI ,  Haiqing BAI ,  Donald E. INGBER ,  Crystal Yuri OH ,  Rachelle PRANTIL-BAUN

IPC分类号： C12N15/117 ,  A61K45/06 ,  A61K31/713 ,  A61P31/16 ,  A61P31/14 ,  A61K35/16 ,  A61K39/39

CPC分类号： C12N15/117 ,  A61K45/06 ,  A61K31/713 ,  A61P31/16 ,  A61P31/14 ,  A61K35/16 ,  A61K39/39 ,  C12N2310/14 ,  C12N2310/31 ,  A61K2039/55561

摘要： Described herein are compositions and methods for inducing Type I interferon production. The compositions described comprise immunostimulatory oligonucleotide duplexes including a 5′ terminal monophosphate-CUGA-3′ (SEQ ID NO. 1) sequence. Compositions comprising the immunostimulatory oligonucleotide duplexes described can be used for the treatment of diseases or disorders that respond to interferons.

公开(公告)号：US20220412961A1

公开(公告)日：2022-12-29

申请号：US17776687

申请日：2020-11-13

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Pawan JOLLY ,  Helena DE PUIG GUIXE ,  Olivier Yves Frederic HENRY ,  Donald E. INGBER ,  James J. COLLINS ,  Nur MUSTAFAOGLU ,  Nooralhuda ARKAN

IPC分类号： G01N33/52 ,  G01N33/543 ,  C07K16/44

摘要： Embodiments of various aspects described herein are directed to assays and devices for detecting a target molecule in a sample. In particular, there is described a lateral assay comprising a plurality of serially oriented capture zones, where each capture zone independently comprises an immobilized competitive molecule on a lateral flow matrix. The immobilized competitive molecule and the analyte competitively bind with a capture agent capable of binding the analyte.

公开(公告)号：US20210338736A1

公开(公告)日：2021-11-04

申请号：US17366827

申请日：2021-07-02

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Donald E. INGBER ,  Samira MUSAH

IPC分类号： A61K35/22 ,  C12N5/071

摘要： Embodiments of various aspects described herein relate to methods, kits, and cell culture media for generation of podocytes from pluripotent stem (PS) cells, as well as cells produced by the same, and methods of use.

公开(公告)号：US20200291083A1

公开(公告)日：2020-09-17

申请号：US16892577

申请日：2020-06-04

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Michael SUPER ,  Jeffrey Charles WAY ,  Donald E. INGBER

IPC分类号： C07K14/47 ,  G01N33/569 ,  C07K16/44 ,  C07K17/00

摘要： The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

公开(公告)号：US20200079828A1

公开(公告)日：2020-03-12

申请号：US16669805

申请日：2019-10-31

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Alexander L. WATTERS ,  Donald E. INGBER ,  Mark J. CARTWRIGHT ,  Michael SUPER ,  Martin ROTTMAN ,  Evangelia MURRAY ,  Brendon DUSEL

IPC分类号： C07K14/47 ,  A61K47/42 ,  G01N33/569 ,  G01N33/68

摘要： Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

公开(公告)号：US20160296665A1

公开(公告)日：2016-10-13

申请号：US15142421

申请日：2016-04-29

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Donald E. INGBER ,  Javier Gomez FERNANDEZ

IPC分类号： A61L27/24 ,  A61L15/44 ,  A61L15/32 ,  A61L15/28 ,  A61L27/20 ,  A61L27/54

CPC分类号： A61L27/24 ,  A61L15/225 ,  A61L15/28 ,  A61L15/325 ,  A61L15/38 ,  A61L15/425 ,  A61L15/44 ,  A61L15/52 ,  A61L27/20 ,  A61L27/227 ,  A61L27/34 ,  A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  B05D3/104 ,  C08L1/02 ,  C08L3/02 ,  C08L5/00 ,  C08L5/08 ,  C08L5/10 ,  C08L89/00

摘要： The present invention is directed to a composite laminar material with high mechanical strength and methods of fabricating the material. The invention also provides a method of attaching a medical implant device to tissue.

公开(公告)号：US20230358740A1

公开(公告)日：2023-11-09

申请号：US17791609

申请日：2021-01-08

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Mark Joseph CARTWRIGHT ,  Michael SUPER ,  Donald E. INGBER ,  Jennifer GRANT ,  Justin SCOTT ,  Shannon Catherine DUFFY ,  Sahil LOOMBA

IPC分类号： G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56911 ,  G01N33/6851

摘要： The technology described herein is directed to methods for detection of microbes and microbe components. In some embodiments of any of the aspects, the methods comprise methods of microbe isolation, sample preparation, mass spectrometry, or analysis. In some embodiments of any of the aspects, such methods can be applied to detect at least one microbe or at least one microbial component in a sample, including not limited to a patient sample, an animal model sample, an environmental sample, or a non-biological sample.

公开(公告)号：US20230287142A1

公开(公告)日：2023-09-14

申请号：US18014863

申请日：2021-07-06

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Alexander WATTERS ,  Pawan JOLLY ,  Donald E. INGBER ,  Thomas CUNNINGHAM

IPC分类号： C07K16/44 ,  G01N33/68 ,  C12N15/63

CPC分类号： C07K16/44 ,  C12N15/63 ,  G01N33/6812 ,  C07K2317/565 ,  C07K2317/622

摘要： Described herein are polypeptides, compositions, kits, and analyte detection systems for the detection of the presence or absence of small molecules (e.g. histamine and/or histidine) in a test sample.

公开(公告)号：US20230165571A1

公开(公告)日：2023-06-01

申请号：US17922518

申请日：2021-03-19

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Richard NOVAK ,  Donald E. INGBER ,  Manuel Ramsés MARTÍNEZ FLORES

IPC分类号： A61B10/00 ,  A61F13/38

CPC分类号： A61B10/0051 ,  A61F13/38

摘要： The technology described herein is directed to a swab for sample collection. In one aspect, the swab comprises a sample collection head, which comprises a plurality of spaced annular rings. In one embodiment, the swab further comprises a tapered neck and a handle. In one embodiment, the swab is injection-molded using polypropylene. In other aspects, described herein are swabs comprising a water-soluble or biodegradable material. In additional aspects, described herein are kits comprising said swabs and methods of using said swabs.