公开(公告)号：US20230358740A1

公开(公告)日：2023-11-09

申请号：US17791609

申请日：2021-01-08

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Mark Joseph CARTWRIGHT ,  Michael SUPER ,  Donald E. INGBER ,  Jennifer GRANT ,  Justin SCOTT ,  Shannon Catherine DUFFY ,  Sahil LOOMBA

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/56911 ,  G01N33/6851

Abstract: The technology described herein is directed to methods for detection of microbes and microbe components. In some embodiments of any of the aspects, the methods comprise methods of microbe isolation, sample preparation, mass spectrometry, or analysis. In some embodiments of any of the aspects, such methods can be applied to detect at least one microbe or at least one microbial component in a sample, including not limited to a patient sample, an animal model sample, an environmental sample, or a non-biological sample.

公开(公告)号：US20230287142A1

公开(公告)日：2023-09-14

申请号：US18014863

申请日：2021-07-06

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Alexander WATTERS ,  Pawan JOLLY ,  Donald E. INGBER ,  Thomas CUNNINGHAM

IPC: C07K16/44 ,  G01N33/68 ,  C12N15/63

CPC classification number: C07K16/44 ,  C12N15/63 ,  G01N33/6812 ,  C07K2317/565 ,  C07K2317/622

Abstract: Described herein are polypeptides, compositions, kits, and analyte detection systems for the detection of the presence or absence of small molecules (e.g. histamine and/or histidine) in a test sample.

公开(公告)号：US20230165571A1

公开(公告)日：2023-06-01

申请号：US17922518

申请日：2021-03-19

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Richard NOVAK ,  Donald E. INGBER ,  Manuel Ramsés MARTÍNEZ FLORES

IPC: A61B10/00 ,  A61F13/38

CPC classification number: A61B10/0051 ,  A61F13/38

Abstract: The technology described herein is directed to a swab for sample collection. In one aspect, the swab comprises a sample collection head, which comprises a plurality of spaced annular rings. In one embodiment, the swab further comprises a tapered neck and a handle. In one embodiment, the swab is injection-molded using polypropylene. In other aspects, described herein are swabs comprising a water-soluble or biodegradable material. In additional aspects, described herein are kits comprising said swabs and methods of using said swabs.

公开(公告)号：US20220267749A1

公开(公告)日：2022-08-25

申请号：US17698576

申请日：2022-03-18

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Michael SUPER ,  Alexander L. WATTERS ,  Philip T. SNELL ,  Donald E. INGBER

IPC: C12N9/26 ,  A61K38/00 ,  C07K14/805 ,  C12N9/96

Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.

公开(公告)号：US20220145266A1

公开(公告)日：2022-05-12

申请号：US17539452

申请日：2021-12-01

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. INGBER ,  Magdalena KASENDRA ,  Alexandra SONTHEIMER-PHELPS ,  Alessio TOVAGLIERI

IPC: C12N5/071 ,  C12N5/00 ,  G01N33/50

Abstract: Described herein are methods for providing an in vitro intestinal model system, e.g., using primary cells instead of cell lines and/or cancerous cells.

公开(公告)号：US20210388301A1

公开(公告)日：2021-12-16

申请号：US17146264

申请日：2021-01-11

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. INGBER ,  Anthony BAHINSKI ,  Robert CUNNINGHAM ,  Josue A. GOSS ,  Geraldine A. HAMILTON ,  Christopher David HINOJOSA ,  Daniel LEVNER ,  Kevin Kit PARKER

IPC: C12M3/06 ,  A01N1/02 ,  C12M1/34 ,  G01N33/50 ,  B01L3/00 ,  B01L9/00 ,  C12M3/00 ,  C12M1/00 ,  C12M1/42

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

公开(公告)号：US20210277079A1

公开(公告)日：2021-09-09

申请号：US17318343

申请日：2021-05-12

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Alexander L. WATTERS ,  Donald E. INGBER ,  Mark J. CARTWRIGHT ,  Michael SUPER ,  Martin ROTTMAN ,  Evangelia MURRAY ,  Brendon DUSEL

IPC: C07K14/47 ,  G01N33/68 ,  G01N33/569 ,  A61K47/42

Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

公开(公告)号：US20200231822A1

公开(公告)日：2020-07-23

申请号：US16617566

申请日：2018-07-27

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Pawan JOLLY ,  Olivier Yves Frederic HENRY ,  Donald E. INGBER ,  Jonathan SABATE DEL RIO

IPC: C09D5/24 ,  C09D7/61 ,  C09D7/62 ,  C09D189/00 ,  G01N33/543

Abstract: Carbon nanotubes or graphene combined with proteinaceous material forming compositions that can be coated on surfaces are described. For example, the described compositions can be used as a coating on an electrode. The coatings can be functionalized with capture agents, targeting specific analytes. In addition to being conductive, the coatings prevent fouling and passivation of the electrodes by non-specific binding. This allows the coated electrodes to be used in complex matrices such as can be found in biological fluids and tissues. The coated electrodes can be regenerated and reused repeatedly.

公开(公告)号：US20160324897A1

公开(公告)日：2016-11-10

申请号：US15111999

申请日：2015-01-16

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Donald E. INGBER ,  Anne-Laure PAPA

IPC: A61K35/19 ,  C12N5/078

CPC classification number: A61K35/19 ,  A61K31/122 ,  A61K31/337 ,  A61K31/37 ,  A61K31/4365 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/64 ,  A61K31/704 ,  A61K31/7068 ,  A61K38/49 ,  C12N5/0644 ,  A61K2300/00

Abstract: The invention provides platelet decoys and mimics that can bind to platelet receptor substrate but do not undergo platelet activation. The invention also provides methods of using the platelet decoys for treating, preventing or inhibiting a disease or disorder in subject when platelet activation, aggregation and/or adhesion contributes to the pathology or symptomology of the disease.

Abstract translation: 本发明提供血小板诱饵和可以结合血小板受体底物但不经历血小板活化的模拟物。 本发明还提供了当血小板活化，聚集和/或粘附有助于疾病的病理学或症状学时，使用血小板诱饵来治疗，预防或抑制受试者的疾病或病症的方法。

公开(公告)号：US20160146810A1

公开(公告)日：2016-05-26

申请号：US14904583

申请日：2014-07-15

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Mark J. CARTWRIGHT ,  Nazita GAMINI ,  Donald E. INGBER ,  Martin ROTTMAN ,  Michael SUPER ,  Julie A. TOMOLONIS ,  Karen A. SINCLAIR

IPC: G01N33/569

CPC classification number: G01N33/56911 ,  C12Q1/18 ,  G01N33/5695 ,  G01N33/56961 ,  G01N2333/4724 ,  G01N2400/00 ,  G01N2800/26 ,  G01N2800/52

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

Abstract translation: 本公开提供用于增强样品中微生物检测和监测受试者中抗微生物活性的方法，组合物和试剂盒。