公开(公告)号：US10603311B2

公开(公告)日：2020-03-31

申请号：US15052368

申请日：2016-02-24

Applicant: PRILENIA NEUROTHERAPEUTICS LTD.

Inventor： Michal Geva ,  Ilya Bezprozvanny ,  Merav Bassan ,  Michael Hayden

IPC: A61K31/451 ,  C07D211/24 ,  C07D211/52 ,  C07D211/42

Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject.The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.

公开(公告)号：US20240041855A1

公开(公告)日：2024-02-08

申请号：US18491871

申请日：2023-10-23

Applicant: Prilenia Neurotherapeutics Ltd.

Inventor： Daniella LICHT ,  Ioana Lovinger ,  Laura Yehudit Guilatt ,  Merav Bassan

IPC: A61K31/451 ,  A61K9/16 ,  A61K9/20

CPC classification number: A61K31/451 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2068

Abstract: The subject invention provides a modified release solid oral dosage form comprising a therapeutically effective amount of Pridopidine or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable rate controlling excipient, wherein the solid oral dosage form provides an in vivo plasma pridopidine concentration profile having a Mean Cmax of about 1,400 ng/ml or less. The subject invention also provides a method of treating an individual afflicted with a neurodegenerative disease or disease related to dopamine, comprising once daily administration of a modified release solid oral dosage form.

公开(公告)号：US20200093813A1

公开(公告)日：2020-03-26

申请号：US16591875

申请日：2019-10-03

Applicant: PRILENIA NEUROTHERAPEUTICS LTD. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michal Geva ,  Ilya Bezprozvanny ,  Merav Bassan ,  Michael Hayden

IPC: A61K31/451 ,  A61P25/28 ,  A61P25/08

Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject.The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.

公开(公告)号：US11471449B2

公开(公告)日：2022-10-18

申请号：US16591875

申请日：2019-10-03

Applicant: PRILENIA NEUROTHERAPEUTICS LTD. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Michal Geva ,  Ilya Bezprozvanny ,  Merav Bassan ,  Michael Hayden

IPC: A61P25/08 ,  A61K31/451 ,  A61P25/28 ,  A61K45/06

Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject.
The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.

公开(公告)号：US20210308115A1

公开(公告)日：2021-10-07

申请号：US17352305

申请日：2021-06-20

Applicant: PRILENIA NEUROTHERAPEUTICS LTD.

Inventor： Merav Bassan ,  Esther Lukasiewicz Hagai ,  Eli Eyal ,  Anna Kristina Sveinsdotter Teige Wickenberg

IPC: A61K31/451 ,  A61P25/28 ,  A61K9/00

Abstract: A method of treating a human patient afflicted with Huntington's disease, comprising periodically orally administering to the patient a pharmaceutical composition comprising pridopidine, its analog or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11090297B2

公开(公告)日：2021-08-17

申请号：US16438508

申请日：2019-06-12

Applicant: PRILENIA NEUROTHERAPEUTICS LTD.

Inventor： Merav Bassan ,  Esther Lukasiewicz Hagai ,  Eli Eyal ,  Anna Kristina Sveinsdotter Teige Wickenberg

IPC: A61K31/451 ,  A61P25/28 ,  A61K9/00

Abstract: A method of treating a human patient afflicted with Huntington's disease, comprising periodically orally administering to the patient a pharmaceutical composition comprising pridopidine, its analog or a pharmaceutically acceptable salt thereof.