公开(公告)号：US09884802B2

公开(公告)日：2018-02-06

申请号：US14775882

申请日：2014-03-14

申请人： PROMETIC BIOSCIENCES INC.

发明人： Lyne Gagnon ,  Pierre Laurin ,  Brigitte Grouix ,  Lilianne Geerts ,  François Sarra-Bournet ,  Martin Leduc ,  Shaun Abbott ,  Boulos Zacharie ,  Jean-François Bienvenu ,  Valérie Perron

IPC分类号： C07C57/30 ,  A61K31/192 ,  C07C59/52 ,  C07C57/58 ,  C07C57/42 ,  C07C57/60 ,  C07C59/84 ,  A61K31/4418 ,  A61K45/06

CPC分类号： C07C57/30 ,  A61K31/192 ,  A61K31/4418 ,  A61K45/06 ,  C07C57/42 ,  C07C57/58 ,  C07C57/60 ,  C07C59/52 ,  C07C59/84 ,  Y02A50/423

摘要： The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2—OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH.

公开(公告)号：US10023518B2

公开(公告)日：2018-07-17

申请号：US14776328

申请日：2014-03-14

申请人： PROMETIC BIOSCIENCES INC.

发明人： Boulos Zacharie ,  Shaun Abbott ,  Lyne Gagnon ,  Pierre Laurin ,  Brigitte Grouix

IPC分类号： C07C53/134 ,  A61K31/192 ,  C07C59/52 ,  C07C57/30 ,  C07C57/58

摘要： The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.