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    SALTS AND ESTERS OF APX3330 AND THERAPEUTIC USES THEREOF
    1.
    发明公开
    SALTS AND ESTERS OF APX3330 AND THERAPEUTIC USES THEREOF 审中-公开

    公开(公告)号：US20240101505A1

    公开(公告)日：2024-03-28

    申请号：US18367631

    申请日：2023-09-13

    申请人： Ocuphire Pharma, Inc.

    发明人： Daniela Carmen ONICIU ,  Maria-Andreea LUNGAN ,  Andrei-Alunel PATRASCU ,  Corina-Mihaela MANTA ,  Anthony CARESTIA ,  Jon HOUSLEY

    IPC分类号： C07C57/42 ,  C07C69/88

    CPC分类号： C07C57/42 ,  C07C69/88 ,  C07B2200/13

    摘要： This invention relates to Compound 1 (APX3330) salts and esters. The invention also provides compositions comprising a Compound 1 salt or ester. The invention also provides compounds of formula (I) and formula (II) and pharmaceutically acceptable salts thereof. The invention further provides compositions comprising a compound of formula (I) or formula (II), or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or vehicle. The invention also provides methods for treating or preventing a disease, such as cancer, a liver disorder, an ocular disorder, a cardiovascular disorder, fibrosis, or an inflammatory disorder, comprising administering to a subject in need thereof an effective amount of a Compound 1 salt or ester; or compound of formula (I) or formula (II), or pharmaceutically acceptable salt thereof.

    PHENYL (METH)ACRYLATE PRODUCTION METHOD AND PHENYL (METH)ACRYLATE COMPOSITION
    5.
    发明申请
    PHENYL (METH)ACRYLATE PRODUCTION METHOD AND PHENYL (METH)ACRYLATE COMPOSITION 有权
    丙烯酸（甲基）丙烯酸酯生产方法和丙烯酸（甲基）丙烯酸酯组合物

    公开(公告)号：US20170022136A1

    公开(公告)日：2017-01-26

    申请号：US15284750

    申请日：2016-10-04

    申请人： MITSUBISHI RAYON CO., LTD.

    发明人： Ryo Aizawa ,  Takeshi Matsuo ,  Naoshi Murata ,  Hiroyuki Mori

    IPC分类号： C07C57/42

    CPC分类号： C07C57/42 ,  C07C67/10 ,  C07C67/11 ,  C07C67/62 ,  C07C69/54

    摘要： Provided is a method that can produce phenyl(meth)acrylate inexpensively and at high yields. The phenyl(meth)acrylate production method of the present invention reacts (meth)acrylic acid with carbonic acid diphenyl. Further, the phenyl(meth)acrylate composition of the present invention contains 90-99.999 wt % phenyl(meth)acrylate and 0.001-10% carbonic acid diphenyl. Or, the phenyl(meth)acrylate composition of the present invention contains 90-99.999 wt % phenyl(meth)acrylate and 0.001-10 wt % of a specified compound.

    摘要翻译： 提供能够以高收率廉价地生产（甲基）丙烯酸苯酯的方法。 本发明的（甲基）丙烯酸苯酯制备方法使（甲基）丙烯酸与碳酸二苯反应。 此外，本发明的（甲基）丙烯酸苯酯组合物含有90-99.999重量％的（甲基）丙烯酸苯酯和0.001-10％的碳酸二苯基酯。 或者，本发明的（甲基）丙烯酸苯酯组合物含有90-99.999重量％的（甲基）丙烯酸苯酯和0.001-10重量％的特定化合物。

    POLYMERIZABLE COMPOUND, AND LIQUID CRYSTAL COMPOSITION PRODUCED USING SAME
    7.
    发明申请
    POLYMERIZABLE COMPOUND, AND LIQUID CRYSTAL COMPOSITION PRODUCED USING SAME 审中-公开
    可聚合的化合物和使用其制备的液晶组合物

    公开(公告)号：US20160137921A1

    公开(公告)日：2016-05-19

    申请号：US14778795

    申请日：2014-03-18

    申请人： DIC CORPORATION

    发明人： Masanao Hayashi ,  Masahiro Horiguchi ,  Tetsuo Kusumoto

    IPC分类号： C09K19/20 ,  C09K19/38 ,  C09K19/32 ,  C07C57/42 ,  C07C65/28

    CPC分类号： C09K19/2014 ,  C07C57/42 ,  C07C65/28 ,  C08F22/20 ,  C09K19/2028 ,  C09K19/322 ,  C09K19/3852 ,  C09K19/3861 ,  C09K2019/0448 ,  C09K2019/2078 ,  C09K2019/3027 ,  C09K2019/323 ,  C09K2019/3425 ,  G02F1/13363 ,  G02F1/133711

    摘要： The polymerizable composition and the liquid crystal composition containing the polymerizable compound of the present invention have favorable storage stability as evaluated on the basis of the occurrence of precipitation, separation, or the like of crystals during storage. The present invention relates to a polymerizable compound, a liquid crystal composition which contains the compound, and further a liquid crystal display element which contains an optically anisotropic material which is a cured product of the liquid crystal composition, or a cured product which controls alignment of liquid crystal molecules. That is, the present invention relates to a polymerizable compound, and a liquid crystal composition containing the polymerizable compound which contains the polymerizable compound and a liquid crystal compound. The polymerizable compound is a compound represented by General Formula (I), and is useful for an optically anisotropic material, a retardation layer, an alignment film, or a polarizing layer.

    摘要翻译： 含有本发明的聚合性化合物的聚合性组合物和液晶组合物，根据储存时析出，分离等晶体的发生情况进行评价，具有良好的保存稳定性。 本发明涉及可聚合化合物，含有该化合物的液晶组合物，还包含含有作为液晶组合物的固化产物的光学各向异性材料的液晶显示元件或控制 液晶分子。 也就是说，本发明涉及可聚合化合物和含有可聚合化合物的液晶组合物和含有可聚合化合物的液晶组合物。 可聚合化合物是由通式（I）表示的化合物，可用于光学各向异性材料，延迟层，取向膜或偏振层。