公开(公告)号：US20180148719A1

公开(公告)日：2018-05-31

申请号：US15570103

申请日：2016-06-06

申请人： PROTIVA BIOTHERAPEUTICS, INC.

发明人： Amy C. H. LEE ,  Nicholas D. WEBER

IPC分类号： C12N15/113 ,  C12N9/22 ,  C07K7/06 ,  A61K9/51 ,  A61K48/00

CPC分类号： C12N15/113 ,  A61K9/127 ,  A61K9/5123 ,  A61K9/5146 ,  A61K48/0025 ,  C07K7/06 ,  C12N9/22 ,  C12N15/111 ,  C12N15/1131 ,  C12N15/1137 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2320/32

摘要： The present invention provides lipid particles comprising therapeutic nucleic acids such as gRNA that target gene expression.

公开(公告)号：US20180245074A1

公开(公告)日：2018-08-30

申请号：US15570111

申请日：2016-06-06

申请人： PROTIVA BIOTHERAPEUTICS, INC.

发明人： Amy C. H. LEE ,  Nicholas D. WEBER

IPC分类号： C12N15/11 ,  A61K9/50 ,  C12N9/22 ,  C12N15/90 ,  A61P31/20

CPC分类号： C12N15/11 ,  A61K9/127 ,  A61K9/5015 ,  A61K38/00 ,  A61P31/20 ,  C12N9/22 ,  C12N15/1131 ,  C12N15/1137 ,  C12N15/907 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2320/32 ,  C12N2800/80

摘要： The present invention provides compositions comprising therapeutic nucleic acids such as gRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).

公开(公告)号：US20180016583A1

公开(公告)日：2018-01-18

申请号：US15515952

申请日：2015-10-01

申请人： PROTIVA BIOTHERAPEUTICS, INC.

发明人： Jennifer L. CROSS ,  Ammen P. DHILLON ,  Amy C. H. LEE ,  Ian MACLACHLAN ,  Nicholas M. SNEAD ,  Emily P. THI

IPC分类号： C12N15/113 ,  A61K47/24 ,  A61K47/18 ,  A61K9/14 ,  A61K47/28 ,  A61K31/713

CPC分类号： C12N15/1131 ,  A61K9/14 ,  A61K31/713 ,  A61K47/18 ,  A61K47/24 ,  A61K47/28 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/323 ,  C12N2310/3521 ,  A61K2300/00

摘要： The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target Hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating HBV infection and/or HDV infection in humans).

公开(公告)号：US20180245077A1

公开(公告)日：2018-08-30

申请号：US15558390

申请日：2016-03-21

申请人： PROTIVA BIOTHERAPEUTICS, INC.

发明人： Ting CHIU ,  Narayanan HARIHARAN ,  Amy C. H. LEE ,  Christopher Justin PASETKA ,  Janet Ruth PHELPS ,  Nicholas Michael SNEAD ,  Andrew Anthony WIECZOREK

IPC分类号： C12N15/113 ,  A61P3/06

CPC分类号： C12N15/113 ,  A61P3/06 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/33 ,  C12N2310/3515 ,  C12N2320/31 ,  C12N2320/32 ,  C12N2310/3521

摘要： The present invention provides compositions comprising therapeutic nucleic acids such as siRNA that target ApoC3 and ANGPTL3 expression, lipid particles comprising one or more (e.g., a combination) of the therapeutic nucleic acids, and methods of delivering and/or administering the lipid particles (e.g., for treating hypertriglyceridemia in humans).