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公开(公告)号：US20170260523A1
公开(公告)日：2017-09-14
申请号：US15342020
申请日：2016-11-02
发明人： ED YAWORSKI , LLOYD B. JEFFS , LORNE R. PALMER
IPC分类号： C12N15/113 , A61K9/50
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/1272 , A61K9/1274 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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公开(公告)号：US20160251681A1
公开(公告)日：2016-09-01
申请号：US15153487
申请日：2016-05-12
发明人： ED YAWORSKI , LLOYD B. JEFFS , LORNE R. PALMER
IPC分类号： C12N15/88 , A61K9/51 , A61K31/713 , C12N15/113 , A61K47/48
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/1272 , A61K9/1274 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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