公开(公告)号：US20230348372A1

公开(公告)日：2023-11-02

申请号：US17995886

申请日：2021-04-01

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Stephane QUERU ,  Babak SAYAH ,  Nicolas DRILLAUD ,  Nicolas LOPEZ

IPC: C07C315/02 ,  C07C315/06

CPC classification number: C07C315/02 ,  C07C315/06 ,  C07B2200/13

Abstract: A process for synthesizing a compound of formula (I)




including: (a) condensing the benzaldehyde compound of formula (II) with the dialkylaniline of formula (III) to give the triphenylmethane of formula (IV); (b) treating the triphenylmethane of formula (IV) with sulfuric acid to form the triphenylmethane sulfone of the formula (V); and (c) oxidizing the triphenylmethane sulfone of formula (V) with a quinone. Such a process may be used to prepare patent blue.

公开(公告)号：US20230159444A1

公开(公告)日：2023-05-25

申请号：US17995881

申请日：2021-04-01

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Stephane QUERU ,  Babak SAYAH ,  Nicolas DRILLAUD ,  Nicolas LOPEZ

IPC: C07C303/06 ,  C09B11/12 ,  C09B11/22

CPC classification number: C07C303/06 ,  C09B11/12 ,  C09B11/22 ,  C07B2200/13

Abstract: A process for preparing a compound of formula




including oxidizing the triphenylmethane sulfone of formula (V) with a quinone chosen from 1,4-benzoquinone, 1,2-benzoquinone, a di(C1-C4)alkyl-1,4-benzoquinone, a di(C1-C4)alkyl-1,2-benzoquinone, a mono(C1-C4)alkyl-1,4-benzoquinone and a mono(C1-C4)alkyl-1,2-benzoquinone. A crystalline form of patent blue, sodium salt, can be achieved.