公开(公告)号：US20240299549A1

公开(公告)日：2024-09-12

申请号：US18549369

申请日：2022-03-14

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Marina LAURENT ,  Babak SAYAH ,  Nicolas LOPEZ

IPC: A61K47/22 ,  A61K9/08 ,  A61K31/403 ,  A61K41/00 ,  A61K47/02 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K49/00

CPC classification number: A61K47/22 ,  A61K9/08 ,  A61K31/403 ,  A61K41/0057 ,  A61K47/02 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K49/0034

Abstract: An aqueous composition, containing indocyanine green (a), and a compound (b) chosen from ascorbic acid, its salts, and mixtures thereof. A weight ratio of compound (b) to indocyanine green (a) ranges from 0.15 to 15 and a concentration of the indocyanine green (a) in the aqueous composition is between 0.1 and 30 mg/ml.

公开(公告)号：US20240165275A1

公开(公告)日：2024-05-23

申请号：US18549373

申请日：2022-03-14

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Marina LAURENT ,  Babak SAYAH ,  Nicolas LOPEZ

IPC: A61K49/00 ,  A61K47/18 ,  C07D403/06

CPC classification number: A61K49/0034 ,  A61K47/183 ,  C07D403/06

Abstract: A composition, containing 10 to 70% of indocyanine green, 0.1 to 15% of ethylenediaminetetraacetic acid (EDTA) and/or one or more salts thereof, 1 to 20% of histidine, and 20 to 80% of sodium chloride. The percentages are expressed by weight relative to a total weight of the indocyanine green, EDTA, histidine, and sodium chloride.

公开(公告)号：US20200283632A1

公开(公告)日：2020-09-10

申请号：US16884107

申请日：2020-05-27

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Babak SAYAH ,  Stéphane QUERU ,  Michel FERAUD ,  Nicolas LOPEZ

IPC: C09B7/02 ,  A23L5/47 ,  A61K47/22 ,  C09B67/54

Abstract: Process for preparing disodium 5,5′-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5′-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5′-indigosulfonic acid, iii) the leuco-5,5′-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5′-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5′-indigosulfonate.

公开(公告)号：US20240156991A1

公开(公告)日：2024-05-16

申请号：US18549378

申请日：2022-03-14

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Marina LAURENT ,  Babak SAYAH ,  Florian COURIVAUD ,  Nicolas LOPEZ

IPC: A61K49/00 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22

CPC classification number: A61K49/0034 ,  A61K47/183 ,  A61K47/20 ,  A61K47/22

Abstract: A composition, containing indocyanine green (a), and histidine (b). A weight ratio of histidine (b)/indocyanine green (a) is greater than 0.05. A kit for preparing the composition, containing in separate compartments the indocyanine green (a), and an aqueous solution including the histidine (b). The composition is a medicament or a diagnostic agent.

公开(公告)号：US20230348372A1

公开(公告)日：2023-11-02

申请号：US17995886

申请日：2021-04-01

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Stephane QUERU ,  Babak SAYAH ,  Nicolas DRILLAUD ,  Nicolas LOPEZ

IPC: C07C315/02 ,  C07C315/06

CPC classification number: C07C315/02 ,  C07C315/06 ,  C07B2200/13

Abstract: A process for synthesizing a compound of formula (I)




including: (a) condensing the benzaldehyde compound of formula (II) with the dialkylaniline of formula (III) to give the triphenylmethane of formula (IV); (b) treating the triphenylmethane of formula (IV) with sulfuric acid to form the triphenylmethane sulfone of the formula (V); and (c) oxidizing the triphenylmethane sulfone of formula (V) with a quinone. Such a process may be used to prepare patent blue.

公开(公告)号：US20230159444A1

公开(公告)日：2023-05-25

申请号：US17995881

申请日：2021-04-01

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Stephane QUERU ,  Babak SAYAH ,  Nicolas DRILLAUD ,  Nicolas LOPEZ

IPC: C07C303/06 ,  C09B11/12 ,  C09B11/22

CPC classification number: C07C303/06 ,  C09B11/12 ,  C09B11/22 ,  C07B2200/13

Abstract: A process for preparing a compound of formula




including oxidizing the triphenylmethane sulfone of formula (V) with a quinone chosen from 1,4-benzoquinone, 1,2-benzoquinone, a di(C1-C4)alkyl-1,4-benzoquinone, a di(C1-C4)alkyl-1,2-benzoquinone, a mono(C1-C4)alkyl-1,4-benzoquinone and a mono(C1-C4)alkyl-1,2-benzoquinone. A crystalline form of patent blue, sodium salt, can be achieved.

公开(公告)号：US20190292370A1

公开(公告)日：2019-09-26

申请号：US16465040

申请日：2017-11-27

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Babak SAYAH ,  Stéphane QUERU ,  Michel FERAUD ,  Nicolas LOPEZ

IPC: C09B7/02 ,  C09B67/54 ,  A61K47/22 ,  A23L5/47

Abstract: Process for preparing disodium 5,5′-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5′-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5′-indigosulfonic acid, iii) the leuco-5,5′-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5′-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5′-indigosulfonate.