公开(公告)号：US20200283632A1

公开(公告)日：2020-09-10

申请号：US16884107

申请日：2020-05-27

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Babak SAYAH ,  Stéphane QUERU ,  Michel FERAUD ,  Nicolas LOPEZ

IPC: C09B7/02 ,  A23L5/47 ,  A61K47/22 ,  C09B67/54

Abstract: Process for preparing disodium 5,5′-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5′-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5′-indigosulfonic acid, iii) the leuco-5,5′-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5′-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5′-indigosulfonate.

公开(公告)号：US20200010438A1

公开(公告)日：2020-01-09

申请号：US16490480

申请日：2018-02-16

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Michel FERAUD ,  Babak SAYAH ,  Stéphane QUERU ,  Marina LAURENT

IPC: C07D285/15

Abstract: Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and includes the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.

公开(公告)号：US20210323937A1

公开(公告)日：2021-10-21

申请号：US17362283

申请日：2021-06-29

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Michel FERAUD ,  Babak SAYAH ,  Stéphane QUERU ,  Marina LAURENT

IPC: C07D285/15

Abstract: Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and includes the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.

公开(公告)号：US20190292370A1

公开(公告)日：2019-09-26

申请号：US16465040

申请日：2017-11-27

Applicant: PROVEPHARM LIFE SOLUTIONS

Inventor： Babak SAYAH ,  Stéphane QUERU ,  Michel FERAUD ,  Nicolas LOPEZ

IPC: C09B7/02 ,  C09B67/54 ,  A61K47/22 ,  A23L5/47

Abstract: Process for preparing disodium 5,5′-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5′-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5′-indigosulfonic acid, iii) the leuco-5,5′-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5′-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5′-indigosulfonate.