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公开(公告)号：US11939432B2
公开(公告)日：2024-03-26
申请号：US17239133
申请日：2021-04-23
发明人： Yu-Chia Chang , Yunn-Kuen Chang , Wen-Yen Huang , Ging-Ho Hsiue , Hsieh-Chih Tsai , Shuian-Yin Lin , Nai-Sheng Hsu , Tzu-Yu Lin
CPC分类号： C08G81/00 , A61K31/337 , A61K47/34 , A61L31/041 , A61L31/06 , A61L31/16 , C08L71/02 , A61L2300/216 , A61L2300/416 , A61L2300/424
摘要： Synthetic amino acid-modified polymers and methods of making the same and using the same are disclosed. The synthetic amino acid-modified polymers possess distinct thermosensitive, improved water-erosion resistant, and enhanced mechanical properties, and are suitable of reducing or preventing formation of postoperative tissue adhesions. Additionally, the amino acid-modified polymers can also be used as a vector to deliver pharmaceutically active agents.
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公开(公告)号：US11939431B2
公开(公告)日：2024-03-26
申请号：US17239092
申请日：2021-04-23
发明人： Yu-Chia Chang , Yunn-Kuen Chang , Wen-Yen Huang , Ging-Ho Hsiue , Hsieh-Chih Tsai , Shuian-Yin Lin , Nai-Sheng Hsu , Tzu-Yu Lin
CPC分类号： C08G81/00 , A61K31/337 , A61K47/34 , A61L31/041 , A61L31/06 , A61L31/16 , C08L71/02 , A61L2300/216 , A61L2300/416 , A61L2300/424
摘要： The present invention relates to a composition comprising an amino acid-modified polymer, a carboxypolysaccharide, and may further include a metal ion for anti-adhesion and vector application. More specifically, the invention relates to a thermosensitive composition having enhanced mechanical and improved water-erosion resistant properties for efficiently preventing tissue adhesions and can serve as a vector with bio-compatible, bio-degradable/absorbable, and in-vivo sustainable properties.
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